期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 220, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112912
关键词
Plant polyphenols; Multifunctional nanomaterials; Organic absorber; UV photoprotection
资金
- National Natural Science Foundation of China [31872750]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC21036]
This article introduces a method of preparing broad-spectrum sunscreen by combining conventional UV absorbers with biocompatible natural products using nanotechnology. The molecular assembly of EGCG/ABA nanoparticles with good biocompatibility and antioxidant activity was successfully achieved. The sunscreen shows excellent UV protection and has the potential to promote the development of biosafe sunscreens.
Applying sunscreen is a common, convenient, and effective measure to protect skin from ultraviolet (UV) damage, but most of UV absorbers in the present commercially available sunscreens are accompanied with the insufficiencies in terms of efficacy and biosafety. The use of nanotechnology to combine conventional UV absorbers with biocompatible natural products is a feasible strategy to combat these deficiencies. Herein, a simple, green and engineering preparation of broad-band sunscreens was demonstrated by the molecular assembly of a UV absorber aminobenzoic acid (ABA) and polyphenol extracted from green tea (EGCG). Spherical and negatively-charged EGCG/ABA nanoparticles (EA NPs) were simply synthesized with a wide range of particle size from 54.6 to 715.1 nm. These NPs had the satisfactory biocompatibility and antioxidative activity, and could protect fibroblasts from oxidative-stress damage. The formulations containing 10 wt% EA NPs further exhibited broad-spectrum UV absorption and lower UV transmittance than commercial sunscreens. It is believed that this study would spur the utilization of natural reproducible sources for developing biosafe sunscreens with strong anti-UV capability. Indeed, this simple nanotechnology aimed at tackling the biosafe risk of conventional UV absorbers provides a feasible solution strategy with green tea extracts.
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