期刊
COLLOID AND POLYMER SCIENCE
卷 301, 期 3, 页码 273-281出版社
SPRINGER
DOI: 10.1007/s00396-023-05066-5
关键词
Chitosan; Gelatin; Gold nanoparticles; Nanogel; Enzyme-responsive; Breast cancer
In this study, a chitosan/gelatin hybrid nanogel containing gold nanoparticles (CS/AuNPs@Gel) was prepared as an efficient enzyme-responsive carrier for doxorubicin (DOX) delivery. The physicochemical properties of the nanogel were investigated, and it was found that DOX was loaded in the nanogel with a high efficiency and released in an enzyme-responsive manner. Cytotoxic assays demonstrated the effectiveness of the drug-loaded nanogel compared to free DOX.
Here, chitosan/gelatin hybrid nanogel containing gold nanoparticles (CS/AuNPs@Gel) was prepared as an efficient enzyme-responsive carrier for doxorubicin (DOX) delivery. Nanogel was fabricated via ionic crosslinking of CS/AuNPs in the presence of gelatin as an enzyme-responsive moiety. The physicochemical properties of the final compounds were investigated by FT-IR, DLS, TEM, and UV-Vis spectroscopy. The mean size of the prepared CS/AuNPs and CS/AuNPs@Gel was around 83 nm and 119.3 nm with a zeta potential of 83.9 mV and 31.9 mV, respectively. The loading efficiency of DOX in the CS/AuNPs@Gel nanogel was about 56% and DOX was released from the nanogel in an enzyme-responsive manner. The cytotoxic assay on the MCF-7 cells revealed the nontoxicity of free nanogel, the effectiveness of drug-loaded nanogel (DN), and DN in the presence of an enzyme compared with the free DOX.
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