期刊
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
卷 22, 期 10, 页码 1484-1492出版社
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527322666221102141002
关键词
Nociception; neuropathic pain; plasticity; therapeutic; brain; interaction
Considerable functional and structural alterations in the central nervous system (CNS) contribute to chronic pain syndromes. Sensitization of the peripheral or central nervous system can result in stimulus-induced pain. Disease-induced plasticity at both structural and functional levels is evident in various clinical entities. In this article, we review plasticity-induced pain, the pain matrix, and CNS alterations in long-lasting pain, as well as clinical treatment for pathological pain.
Considerable functional and structural alterations, or plasticity, in the central nervous system (CNS) are accompanied by numerous chronic pain syndromes. Sensitization of the peripheral (primary hyperalgesia) or central (secondary hyperalgesia) nervous system as unhelpful neuroplasticity may result in stimulus-induced pain (hyperalgesia and allodynia). Furthermore, nociception induces extensive plasticity in the peripheral and central neural systems in pathological disease states. Disease-induced plasticity at both structural and functional levels is evident as alterations in different molecules, synapses, cellular function and network activity. In the present article, we review plasticity-induced pain and pain-induced plasticity. Moreover, we will review the pain matrix. Furthermore, we will focus on recent developments of CNS alterations in long-lasting pain in some clinical entities encountered in rehabilitation. These clinical entities comprise nonspecific low back pain, complex regional pain syndrome, postamputation phantom pain, fibromyalgia, and chronic pain after spinal cord injury. Moreover, we will review the clinical treatment for the inhibition of pathological pain.
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