☆ 4.7 Editorial Material

Platform trials as the way forward in infectious disease' clinical research: the case of coronavirus disease 2019

CLINICAL MICROBIOLOGY AND INFECTION (2023)

Randomised clinical trials in critical care: past, present and future

Anders Granholm et al.

Summary: Randomised clinical trials are important in providing unbiased evidence of intervention effects. Current critical care RCTs face challenges such as overly optimistic effect sizes and limited focus on patient-centered outcomes. Novel methods, including research program approaches and alternative outcome choices, may offer solutions to these challenges.

INTENSIVE CARE MEDICINE (2022)

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Article Infectious Diseases

The European clinical research response to optimise treatment of patients with COVID-19: lessons learned, future perspective, and recommendations

Herman Goossens et al.

Summary: The article discusses how the clinical research community responded to the pandemic in Europe and provides recommendations for future clinical research response during pandemics. The focus is on two platform trials: RECOVERY and REMAP-CAP, and challenges such as contracting, regulatory hurdles, and competition with national trials are identified. Suggestions for improvement include the creation of structures and partnerships, simplification of trial delivery, development of digital models and procedures, and the establishment of global clinical trial networks.

LANCET INFECTIOUS DISEASES (2022)

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Article Infectious Diseases