Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 (COVID-19) Lower Respiratory Tract Disease in a B-cell Acute Lymphoblastic Leukemia (ALL) Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir

A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery.

Automated summary

This case study describes a patient with B-cell ALL and SARS-CoV-2 who experienced persistent pneumonia and viremia despite various treatments, but achieved full recovery with a combination therapy of nirmatrelvir/ritonavir and remdesivir.