4.7 Article

Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma

期刊

CLINICAL IMMUNOLOGY
卷 245, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2022.109178

关键词

VISTA; PD-L1; Glioma; mIF; B7-H3

资金

  1. 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC18007]
  2. Key research and development project of science and technology department of Sichuan Province [2022YFS0321]
  3. National Natural Science Foundation of China [82002648, 82173175, 82102898]
  4. CAMS Innovation Fund for Medical Sciences [2021-I2M-C T-B-096]
  5. National Major Scientific and Technological Special Project for Significant New Drugs Development [2019ZX09301-147]
  6. Innovation Spark Project of Sichuan University [2018SCUH0092]

向作者/读者索取更多资源

Immune checkpoint therapy has shown breakthrough in cancer treatment, but its interaction in glioma remains controversial. In this study, we analyzed transcriptome data and conducted immunofluorescence assay to detect the features of immune checkpoints. We found that B7-H3, VISTA, and PD-L1 were associated with overall survival and grade in glioma.
Immune checkpoint (IC) therapy has led to a breakthrough in cancer treatment. However, the interaction of ICs is controversial in glioma. We detected features of ICs using transcriptome data and a multicolor immunofluorescence assay. We discovered that B7-H3 increased with grade and age and predicted worse overall survival (OS) at the transcriptional and proteomic levels. VISTA and PD-L1 were associated with OS and grade at the RNA level. At the protein level, VISTA was primarily expressed in tumor cells and TAMs. B7-H3 and VISTA were positively correlated with PD-L1. There was a strong correlation between PD-L1 and CD3 and between VISTA and IBA-1. PD-L1 was coexpressed with T cells. VISTA was coexpressed with TAMs. In T cells, we found a strong correlation in ICs, which worsened in TAMs and tumor cells. In conclusion, B7-H3 is a vital prognostic target for immunotherapy. We provided a potential mechanism for the immunosuppressive microenvironment in glioma.

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