Novel homozygous variant of CCIN causes male infertility owing to the abnormal sperm head with a nuclear subsidence phenotype

(A) Characteristics of spermatozoa in asthenoteratozoospermia affected man. (B) Pedigree and Sanger sequencing analysis of the family. (C) The effect of the missense variant in the CCIN gene.

Automated summary

This study investigated the characteristics of spermatozoa in patients with asthenoteratozoospermia and performed pedigree and Sanger sequencing analysis on the family, revealing the effect of a missense variant in the CCIN gene.