4.7 Article

Peripheral and Portal Venous KRAS ctDNA Detection as Independent Prognostic Markers of Early Tumor Recurrence in Pancreatic Ductal Adenocarcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Prognostic role of cell-free DNA biomarkers in pancreatic adenocarcinoma: A systematic review and meta-analysis

Stefania Bunduc et al.

Summary: This systematic review and meta-analysis found that detectable cell-free DNA (cfDNA) biomarkers are associated with accelerated progression and decreased survival in pancreatic ductal adenocarcinoma (PDAC). The presence of circulant-tumor DNA (ctDNA) and KRAS mutations in cfDNA is linked to poorer overall and progression-free survival across various stages of PDAC. In cases where surgery is not feasible, the detection of ctDNA indicates a higher risk of disease progression, while the significance of KRAS mutations detection needs further investigation.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

Article Oncology

Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer

Silvia Waldeck et al.

Summary: The study revealed that intraoperative plasma sampling in early-stage and locally advanced NSCLC patients results in high ctDNA detection rates, and early postoperative ctDNA positivity serves as a prognostic indicator of disease relapse.

MOLECULAR ONCOLOGY (2022)

Article Oncology

Longitudinal analysis of cell-free mutated KRAS and CA 19-9 predicts survival following curative resection of pancreatic cancer

Saskia Hussung et al.

Summary: Integrated analysis of plasma cfKRAS(mut) and CA 19-9 levels provides a promising approach for predicting disease course in patients with PDAC following resection. The dynamic monitoring using cfKRAS(mut) outperformed CA 19-9 in predicting early relapse and poor overall survival.

BMC CANCER (2021)

Review Oncology

A systematic review and meta-analysis of the association between circulating tumor DNA (ctDNA) and prognosis in pancreatic cancer

Deniz Can Guven et al.

Summary: Research suggests that ctDNA could be a promising tool in the early diagnosis of recurrences and tailoring treatment for pancreatic cancer patients, leading to improved survival outcomes.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review

Marisol Huerta et al.

Summary: Pancreatic cancer is a highly challenging and poor prognosis malignancy. Liquid biopsy using circulating tumor DNA (ctDNA) shows great potential as a non-invasive biomarker for early diagnosis, prognosis, and management of the disease, although its sensitivity remains limited and cannot be used as a screening or diagnostic tool.

CANCERS (2021)

Article Cell Biology

Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer

Daniel W. Hagey et al.

Summary: This study focused on extracellular vesicles as an important source of tumor-derived DNA in liquid biopsies, and conducted experiments by collecting blood samples from 17 pancreatic cancer patients. The results showed that tumor-derived DNA was mainly present in LEVs and SEVs in the early stage of disease progression, and in SEVs and SP in the late stage of disease progression.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Article Oncology

Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors

Paul van der Leest et al.

Summary: Monitoring changes in circulating tumor DNA (ctDNA) levels can serve as a proxy for early tumor response to immunotherapy in metastasized non-small-cell lung cancer (NSCLC) patients, correlating with durable clinical benefit (DCB), progression-free survival (PFS), and overall survival (OS). Patients with a significant decrease (>30%) in ctDNA levels show longer PFS and OS, suggesting that ctDNA dynamics is a promising tool for assessing treatment outcomes in NSCLC patients receiving immune checkpoint inhibitors (ICI).

MOLECULAR ONCOLOGY (2021)

Article Gastroenterology & Hepatology

Evaluation of circulating cell-free KRAS mutational status as a molecular monitoring tool in patients with pancreatic cancer

Konstantin Schlick et al.

Summary: This study evaluated the feasibility of using cell-free tumor DNA with KRAS mutation in peripheral blood as a prognostic and predictive marker for chemotherapy monitoring in pancreatic cancer patients. The results showed that patients with detectable KRAS mutations in plasma had worse survival outcomes, and the dynamic assessment of KRAS mutation ratio was significantly associated with tumor response or progression.

PANCREATOLOGY (2021)

Review Biochemistry & Molecular Biology

Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR

Irina Palacin-Aliana et al.

Summary: Cancer remains a major public health challenge worldwide, and molecular pathology profiling is fundamental for tumor diagnosis and therapeutic decisions. Liquid biopsies show potential as a tool for detecting cancer-specific biomarkers, providing information about tumor dynamics.

BIOMEDICINES (2021)

Review Gastroenterology & Hepatology

Application of liquid biopsy for surgical management of pancreatic cancer

Minako Nagai et al.

ANNALS OF GASTROENTEROLOGICAL SURGERY (2020)

Article Gastroenterology & Hepatology

Early Detection of Pancreatic Cancer: Opportunities and Challenges

Aatur D. Singhi et al.

GASTROENTEROLOGY (2019)

Article Oncology

Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer

Vincent P. Groot et al.

CLINICAL CANCER RESEARCH (2019)

Review Oncology

Liquid biopsies

Evi Lianidou et al.

GENES CHROMOSOMES & CANCER (2019)

Review Genetics & Heredity

Current and Emerging Applications of Droplet Digital PCR in Oncology

Susana Olmedillas-Lopez et al.

MOLECULAR DIAGNOSIS & THERAPY (2017)

Review Oncology

Origins, structures, and functions of circulating DNA in oncology

A. R. Thierry et al.

CANCER AND METASTASIS REVIEWS (2016)

Article Multidisciplinary Sciences

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Mark Sausen et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Simon A. Forbes et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Gastroenterology & Hepatology

Predictive and Prognostic Value of CA 19-9 in Resected Pancreatic Adenocarcinoma

Joshua G. Barton et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2009)