Development of desquamation with Staphylococcus aureus colonization in patients with atopic dermatitis under treatment with upadacitinib

We report two patients with atopic dermatitis who were treated with upadacitinib, and later developed desquamation of the face with Staphylococcus aureus colonization. Treatment with ciclosporin and antibiotics was unsuccessful, but both patients improved when treatment was switched to dupilumab.

Automated summary

We present two cases of atopic dermatitis patients who developed desquamation of the face with Staphylococcus aureus colonization after treatment with upadacitinib. Treatment with ciclosporin and antibiotics failed, but both patients showed improvement when switched to dupilumab therapy.