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Review
Biochemistry & Molecular Biology
Qi Yan et al.
Summary: Hepatocellular carcinoma (HCC) has a high incidence and fatality rate, often diagnosed at an advanced stage. Early prevention and detection of HCC are crucial strategies. Traditional methods for HCC detection, apart from liver biopsy, lack high sensitivity and specificity. This review discusses the use of alpha fetoprotein (AFP), lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), protein induced by vitamin K absence or antagonist-II (PIVKA-II), and other biomarkers as reliable tools, especially when used in combination. Liquid biopsy and certain biomarkers like lactic dehydrogenase (LDH) and suppressor of cytokine signaling (SOCS) show promise for post-treatment monitoring. Understanding the diagnostic technology of HCC is important for improving diagnosis and reducing mortality.
Article
Virology
Marwa Hassan et al.
Summary: CD133 polymorphisms are associated with susceptibility and prognosis of viral hepatitis-induced liver cirrhosis and hepatocellular carcinoma. These findings suggest that CD133(+) cells and CD133 polymorphisms may serve as potential predictors for these diseases.
Review
Gastroenterology & Hepatology
Hang Wang et al.
Summary: Hepatocellular carcinoma is a challenging global disease with limitations in diagnosis and treatment. Extracellular vesicles have unprecedented potential in cancer research as antitumor vaccines and drug carriers. In the past decade, the study of extracellular vesicles in hepatocellular carcinoma has made significant progress.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Engineering, Biomedical
Juan Li et al.
Summary: Exosomes, as nanoscale extracellular vesicles, are widely distributed in various biological fluids and can carry tumor-specific molecules. The clinical translation of exosomes remains challenging due to the requirement of large quantities of samples, insufficiency of traditional techniques, and complex isolation methods. Surface-enhanced Raman scattering (SERS) technology provides a sensitive and multiplexed detection method for exosomes without the need for large samples. In this review, SERS-based exosome detection in cancer diagnosis is discussed, providing valuable insights for early cancer detection.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Wubulitalifu Dawuti et al.
Summary: This paper investigates the feasibility of using urine for surface-enhanced Raman spectroscopy (SERS) for the rapid screening of patients with liver cirrhosis and hepatocellular carcinoma (HCC). The results show that urine SERS method can noninvasively identify liver cirrhosis and HCC with high diagnostic sensitivity.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Elisabetta Canetta
Summary: Raman scattering is widely used in cancer nanomedicine for its high spatial resolution, chemical specificity, and multiplexity. Recent advancements in Raman spectroscopy have led to the development of various applications in cancer diagnostics and therapy. Surface-enhanced Raman spectroscopy (SERS) is also utilized in cancer nanomedicine for enhanced Raman signals and applications in cancer diagnosis and immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Shuxia Guo et al.
Summary: Raman spectroscopy is increasingly used in various fields such as biology, forensics, diagnostics, pharmaceutics, and food science. Chemometric techniques are employed to detect and extract subtle differences in Raman spectra from related samples, aiding in differentiation between different cell types and assessing biological sample chemical variances.
Article
Materials Science, Multidisciplinary
Xiaoyu Ma et al.
Summary: This paper presents a novel metasurface design for active phase tuning by integrating a phase-change dielectric into U-shaped meta-atoms, enabling switchable focusing in reflected waves with high contrast ratio. The hybrid design of the phase-change metasurface shows promising potential for compact integration of active photonic devices.
Article
Biochemistry & Molecular Biology
Eric Boateng Osei et al.
Summary: Extracellular vesicles (EVs) ranging in size from 60 to 800 nm were isolated from plasma of control and prostate cancer patients using differential centrifugation and ultrafiltration techniques. Spontaneous Raman and surface-enhanced Raman spectroscopy (SERS) were employed to identify fractions that best discriminate between control and cancer patients, with results showing that EV12 and EV120 fractions provide the most effective separation.
Article
Oncology
Huabing Wei et al.
Summary: Two methods were compared for extracting exosomes from serum samples of lung cancer patients, showing that ultracentrifugation resulted in better morphology and higher yields compared to the precipitation method. The particle size of exosomes obtained by ultracentrifugation was smaller than that obtained by precipitation, indicating possible contamination in the latter method. Overall, ultracentrifugation was found to be superior for exosome extraction from lung cancer patient serum.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Chemistry, Analytical
Chao Song et al.
Review
Oncology
Luca Guerrini et al.
Review
Oncology
Gregory W. Auner et al.
CANCER AND METASTASIS REVIEWS
(2018)
Article
Engineering, Electrical & Electronic
Riad Yahiaoui et al.
IEEE SENSORS JOURNAL
(2016)
Article
Biochemical Research Methods
Holly J. Butler et al.
Article
Multidisciplinary Sciences
Sergei Novikov et al.
SCIENTIFIC REPORTS
(2016)