Activation of Phosphodiesterase 3A: New Hope for Cardioprotection

Review Cardiac & Cardiovascular Systems

Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure

Rima Kamel et al.

Summary: This review discusses the roles of cAMP and cGMP signaling in cardiomyocytes and the various PDE families expressed in the heart, as well as their modifications in pathological cardiac hypertrophy and heart failure. The potential use of specific PDE inhibitors or activators as therapeutic targets in heart failure is also evaluated.

NATURE REVIEWS CARDIOLOGY (2023)

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Article Cell Biology

Compartmentalized cAMP signaling in cardiac ventricular myocytes

Shailesh R. Agarwal et al.

Summary: Activation of different receptors can lead to distinct functional responses in cardiac myocytes through the generation of cAMP. The compartmentation of cAMP signaling involves localized production, breakdown, and diffusion limitations, which play a crucial role in generating receptor-specific responses. Technological advancements have provided critical breakthroughs in understanding these mechanisms, yet gaps still exist in our knowledge of cAMP compartmentation in cardiac myocytes.

CELLULAR SIGNALLING (2022)

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Article Cardiac & Cardiovascular Systems

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage

Maria Ercu et al.

Summary: PDE3A mutations have been found to protect the heart from hypertension-induced cardiac damage by causing adaptive changes and enhancing contractility. These findings could facilitate the development of new treatments to prevent hypertension-induced cardiac damage.

CIRCULATION (2022)

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Article Medicine, General & Internal

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Bin Zhou et al.

Summary: Global prevalence of hypertension doubled from 1990 to 2019, with significant improvements in detection, treatment, and control rates. In 2019, 59% of women and 49% of men with hypertension were previously diagnosed, while treatment rates were 47% for women and 38% for men, with control rates at 23% for women and 18% for men. Disparities exist across countries, with some middle-income nations now outperforming high-income countries in hypertension management.

LANCET (2021)

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Article Multidisciplinary Sciences