Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration

Severe muscle injury is still a challenging clinical problem. Exosomes derived from adipose stem cells (ASC-exos) may be a potential therapeutic tool, but their mechanism is not completely clear. This review aims to elaborate the possible mechanism of ASC-exos in muscle regeneration from the perspective of signal pathways and provide guidance for further study. Literature cited in this review was acquired through PubMed using keywords or medical subject headings, including adipose stem cells, exosomes, muscle regeneration, myogenic differentiation, myogenesis, wingless/integrated (Wnt), mitogen-activated protein kinases, phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/Akt), Janus kinase/signal transducers and activators of transcription, and their combinations. We obtained the related signal pathways from proteomics analysis of ASC-exos in the literature, and identified that ASC-exos make different contributions to multiple stages of skeletal muscle regeneration by those signal pathways.

Automated summary

This review provides insights into the potential mechanism of adipose stem cell-derived exosomes (ASC-exos) in muscle regeneration. The authors discuss various signaling pathways, such as Wnt, MAPK, PI3K/Akt, and JAK/STAT, and how ASC-exos contribute to different stages of skeletal muscle regeneration through these pathways.