期刊
CHEMOSPHERE
卷 313, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2022.137525
关键词
Perfluoroalkyl substances; Cord serum; Influencing factors
The analysis of 19 PFASs in umbilical cord serum samples in China revealed that PFOA was detected in all samples, with PFOS having the highest median concentration. Neonatal birth weight was negatively correlated with long-chain PFOS, and concentrations of certain PFASs differed significantly between birth weight groups. Maternal characteristics such as age, education, diet, and nutritional supplementation during pregnancy can affect PFAS exposure in the fetus.
The demonstrated developmental and reproductive toxicity of perfluorooctanoic acid (PFOA) and per-fluorooctane sulfonate (PFOS), coupled with the increasing production and use of emerging per-and poly-fluoroalkyl substances (PFASs) has resulted in progressively higher human exposure levels. This has raised concerns about PFAS exposure levels in the fetus, which is highly susceptible to the potential effects of hazardous environmental chemicals. However, in utero exposure to PFASs and health implications have not been fully characterized in China. To fill this gap, we analyzed 19 PFASs in umbilical cord serum samples (n = 66). In-formation about the mothers and newborns was obtained through questionnaires. Associations between maternal characteristics and neonatal birth weight and PFAS concentrations were analyzed using nonparametric tests. As results, PFOA was detected in all serum samples. The highest median concentration of PFOS in umbilical serum was 1.092 ng center dot mL-1, followed by perfluoropentanoic acid (median: 0.633 ng center dot mL-1). Trifluroacetic acid and per-fluoropropanoic acid were detected in cord serum for the first time, and their median concentrations were 0.229 and 0.266 ng center dot mL-1, respectively. Neonatal birth weight was negatively correlated with long-chain PFOS (r =-0.319, P < 0.05), and the concentrations of perfluoroundecanoic acid and perfluorododecanoic acid were significantly different between the birth weight groups. Maternal age, maternal education, diet, and nutritional supplementation during pregnancy can all affect umbilical serum exposure to PFASs. These results demonstrate that legacy PFASs remain major contributors to the composition of human PFASs, while the concentration levels of emerging short-chain alternatives have increased significantly. Modifying the mother's diet may reduce the risk of intrauterine PFAS exposure. Special attention to exposure to highly novel PFASs and confirmation of potential determinants should be taken as a priority in the plan for risk management and actions in this area.
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