The development of disposable electrochemical sensor based on MoSe2rGO nanocomposite modified screen printed carbon electrode for amitriptyline determination in the presence of carbamazepine, application in biological and water samples

The present attempt developed a simple sensing system based on the modification of screen-printed carbon electrode (SPCE) with MoSe2/reduced graphene oxide (rGO) nanocomposite (MoSe2-rGO/SPCE) to voltammetrically co-detect amitriptyline and carbamazepine. Different techniques such as field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) were employed to characterize MoSe2-rGO nanocomposite morphology and structure. Moreover, chronoamperometry, differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV) were utilized to explore the electrochemical oxidation of amitriptyline. Data revealed a great current sensitivity for the MoSe2-rGO/SPCE towards amitriptyline. The peak currents of amitriptyline oxidation on the MoSe2-rGO/SPCE had linear dynamic range (0.02-380.0 mu M) and a narrow limit of detection (0.007 mu M). The MoSe2-rGO/SPCE was successful in sensing carbamazepine and amitriptyline in real specimens, with appreciable recovery rates.

Automated summary

This study developed a simple sensing system based on MoSe2-rGO/SPCE for voltammetric co-detection of amitriptyline and carbamazepine, with high sensitivity and narrow detection limit.