期刊
CHEMOSPHERE
卷 308, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2022.136275
关键词
Phthalates; Di-2-ethylhexyl phthalate; Duodenum; Barrier function; Flora derangement
资金
- National Natural Science Foundation of China [32172932]
- Key Program of Natural Science Foundation of Heilongjiang Province of China [ZD2021C003]
- China Agriculture Research System of MOF
- Distinguished Professor of Longjiang Scholars Support Project [T201908]
The toxic effects of DEHP on the duodenum in quails were investigated, revealing that DEHP exposure leads to duodenal barrier defect, breakdown of antimicrobial defense, activation of TLR4 receptors, and oxidative stress, which further promote duodenal damage.
As one of the most used phthalates, Di (2-ethylhexyl) phthalate (DEHP) is a widespread environmental contaminant. Extremely persistent plastic can enter the food chain of animals through the aquatic environment, affect metabolic pathways and cause damage to the digestive system. But the molecular mechanism of its toxic effects on the duodenum in birds has not been elucidated. To investigate the toxicity of phthalates in the duo-denum, quails were gavaged with 250, 500, and 750 mg/kg doses of DEHP for 45 days, and water and oil control groups were retained. This study revealed that subchronic exposure to DEHP could lead to duodenal barrier defect in quail. The damage to duodenum was reflected in a reduction in V/C and tight junction proteins. Moreover, DEHP also led to a breakdown of antimicrobial defenses through the flora derangement, which acted as a biological barrier. The massive presence of Lipopolysaccharide (LPS) led to the activation of TLR4 receptors. In addition, DEHP activated oxidative stress, which synergized the inflammatory response induced by the TLR4-NF kappa B pathway, and further promoted duodenum damage. This study provides a base for the further effect of phthalates on the microbiota-barrier-immune interaction.
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