期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 29, 期 5, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202202240
关键词
aerobic coupling reactions; C(sp(3))-H; heteroarylacylation; indoles; oxidative coupling reactions
An environmentally friendly method for the oxidative coupling of alpha-methyl substituted N-heteroarenes with indoles is reported. This method features simple operation and a wide range of substrates.
Direct oxidative coupling of inert C(sp(3))-H bond has been a great challenge. Herein, an environmentally friendly aerobic oxidative coupling of alpha-methyl substituted N-heteroarenes with indoles is reported. A variety of diheteroaryl ketones were prepared in good yields (up to 72 %). This protocol features simple operation and broad substrates scope (26 examples). Significantly, a plausible mechanism about catalytic cycle was proposed, and two key intermediates were confirmed by high resolution mass spectrometry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据