Chiral Silanols: Strategies and Tactics for Their Synthesis

Silanols are valuable and important compounds, which have found widespread applications in the field of materials science, synthetic chemistry, and medicinal chemistry. Although a handful of approaches have been developed for the synthesis of various silanols, access to enantioenriched silicon-stereogenic silanols remains underdeveloped. This Concept article intends to summarize and highlight recent advances in the construction of silicon-stereogenic silanols and endeavors to encourage further research in this area.

Automated summary

Silanols are valuable compounds with applications in materials science, synthetic chemistry, and medicinal chemistry. Despite some developed approaches for synthesizing various silanols, the access to enantioenriched silicon-stereogenic silanols remains limited. This Concept article summarizes recent advances in constructing silicon-stereogenic silanols and encourages further research in this area.