One-Pot Tandem Coupling Method for the Short-Step Formal Synthesis of Riccardin C

One-pot reactions reduce reagent amounts and circumvent process treatments, such as work-up and purifications in multi-step reactions. In this study, we achieved the formal total synthesis of riccardin C through a one-pot reaction by simultaneously linking four units through two Sonogashira coupling reactions and one Suzuki coupling reaction, followed by reduction and deprotection. Thus, this one-pot method comprised five steps and did not require the purification of intermediate reaction mixtures, which saves resources, such as reagents and solvents, and expedites the work process.

Automated summary

In this study, the formal total synthesis of riccardin C was achieved through a one-pot reaction, which involved simultaneous coupling reactions and subsequent reduction and deprotection. This method streamlined the process by eliminating the need for purification of intermediate reaction mixtures, thus saving resources and expediting the work.