The Antinociceptive Effect of a Hydroalcoholic Extract of Polygala altomontana and Its Chemical Profile Using UPLC-ESI-QTOF-HR-MS

The hydroalcoholic extract of Polygala altomontana (30, 100, and 300 mg/kg, i.g.) showed a dose-dependent antinociceptive action during the inflammatory phase of the formalin test. In addition, the preparation (30 and 300 mg/kg, i.g.) showed anti-hyperalgesic action when tested on a mechanical nociception model. UPLC-ESI-QTOF-MS data indicated the active extract contained phenylpropanoid sucrose esters, glycosylated quercetin derivatives, styrylpyrones, and coumarins. Some identified compounds, including styrylpyrones and coumarins, have previously demonstrated antinociceptive action. The results also show that P. altomontana shows potential for developing pain-relieving herbal remedies and drugs.

Automated summary

The hydroalcoholic extract of Polygala altomontana showed a dose-dependent antinociceptive action in the inflammatory phase of the formalin test and anti-hyperalgesic action in a mechanical nociception model. UPLC-ESI-QTOF-MS analysis revealed the presence of phenylpropanoid sucrose esters, glycosylated quercetin derivatives, styrylpyrones, and coumarins in the active extract. Some identified compounds, such as styrylpyrones and coumarins, have demonstrated antinociceptive action. The results suggest the potential of P. altomontana for developing pain-relieving herbal remedies and drugs.