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Bioactive inorganic nanomaterials for cancer theranostics

CHEMICAL SOCIETY REVIEWS (2023)

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Article Chemistry, Physical

Fe-porphyrin: A redox-related biosensor of hydrogen molecule

Zhaokui Jin et al.

Summary: This study reveals that Fe-porphyrin is a targeted molecule for hydrogen molecules, which can catalytically scavenge OH and reduce CO2 to CO. These findings contribute to a better understanding of the profound biomedical effects of hydrogen molecules, and have implications for the development of innovative drugs and hydrogen energy/agricultural materials.

NANO RESEARCH (2023)

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Article Chemistry, Physical

Fe-porphyrin: A redox-related biosensor of hydrogen molecule

Zhaokui Jin et al.

Summary: The study reveals that Fe-porphyrin is a targeted molecule of hydrogen (H-2), and it can catalytically scavenge oxidation stress products and reduce CO2 into CO. These findings are important for better understanding the biomedical effects of H-2 and for the development of innovative drugs and hydrogen energy/agricultural materials.

NANO RESEARCH (2023)

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Article Nanoscience & Nanotechnology

Efficient Magnetic Nanocatalyst-Induced Chemo- and Ferroptosis Synergistic Cancer Therapy in Combination with T1-T2 Dual-Mode Magnetic Resonance Imaging Through Doxorubicin Delivery

Ling Zhu et al.

Summary: The nanocatalyst ipGdIO-Dox can induce cancer cells to undergo ferroptosis, exhibiting excellent anticancer efficacy and the ability for tumor diagnosis under MRI guidance.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer

Guangbao Yang et al.

Summary: A nanoscale therapeutic system was fabricated by coassembly of human serum albumin and glucose oxidase, which effectively eliminates tumor cells through the combination of catalysis and chemotherapeutic prodrug conversion, demonstrating high therapeutic efficacy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Nano-ultrasonic Contrast Agent for Chemoimmunotherapy of Breast Cancer by Immune Metabolism Reprogramming and Tumor Autophagy

Xupeng Yang et al.

Summary: This study determines that reprogramming the metabolism of immature dendritic cells (iDCs) and tumor-associated macrophages (TAMs) can enhance the ratio of mature dendritic cells (mDCs) and proinflammatory macrophages, thus improving the immune response against triple-negative breast cancer. The findings provide a candidate method for monitoring treatment and augmenting antitumor chemoimmunotherapy by suppressing tumor cell autophagy and reprogramming immunocyte metabolism.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction

Sagang Koo et al.

Summary: The study presents a heterogeneous chemodynamic therapy (CDT) system based on copper-iron peroxide nanoparticles for synergistic therapy in the tumor microenvironment (TME). The system demonstrates excellent tumor therapeutic efficacy by enhancing hydroxyl radical production through a highly efficient catalytic loop. It also generates O-2 and exhibits TME-responsive T-1 magnetic resonance imaging contrast enhancement.

ACS NANO (2022)

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Article Engineering, Biomedical

A tumor microenvironment responsive nanoplatform with oxidative stress amplification for effective MRI-based visual tumor ferroptosis

Shiwei Luo et al.

Summary: Ferroptosis is a promising non-apoptotic regulated cell death form for cancer treatment. However, the efficacy of ferroptosis is limited by high glutathione levels and insufficient hydrogen peroxide levels in tumors. In this study, a theranostic nanoplatform was designed to enhance ferroptosis in the tumor microenvironment by releasing active components, and it was also used for tumor-specific magnetic resonance imaging, exhibiting high specificity and efficacy.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

Assembly of Bioactive Nanoparticles via Metal-Phenolic Complexation

Jingqu Chen et al.

Summary: This study presents a metal-phenolic assembly approach for the easy assembly of diverse functional nanoparticles in water, while preserving their intrinsic activity. These nanoparticles can be applied in fields such as biomedicine and catalysis, showing great potential for various applications.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Engineering Radiosensitizer-Based Metal-Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy

Jie Yan et al.

Summary: This paper proposes a strategy combining radiosensitization and STING pathway activation by fabricating a novel radiosensitizer that releases drugs in a pH-responsive manner. This strategy increases the sensitivity of cancer cells to radiation therapy and promotes immune response, improving the efficacy of cancer radiotherapy.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Engineering Multienzyme-Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

Liang Zhang et al.

Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Bioinspired Five-Coordinated Single-Atom Iron Nanozyme for Tumor Catalytic Therapy

Bolong Xu et al.

Summary: Single-atom nanozymes are a new research frontier in the biomedical fields. A melamine-mediated pyrolysis activation strategy has been used to controllably fabricate iron-based SAzymes with a five-coordinated structure (FeN5). The FeN5 SAzyme shows excellent peroxidase-like activity and significantly enhanced antitumor effect in vitro and in vivo.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Library of ROS-Catalytic Metalloenzyme Mimics with Atomic Metal Centers

Sujiao Cao et al.

Summary: Metal-N-coordinated centers supported by carbonaceous substrates have been synthesized and compared in terms of catalytic activities, substrate selectivities, kinetics, and reactive oxygen species (ROS) products. The electronic structures of the metal centers were found to be highly related to the ROS-catalytic paths and activities.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Bioinspired Lipoproteins of Furoxans-Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T-Cell Infiltration

Yuqi Wang et al.

Summary: In this study, a reduction-sensitive nitric oxide donor conjugate of furoxans-oxaliplatin was synthesized and a stroma-cell-accessible bioinspired lipoprotein system (S-LFO) was designed to facilitate CTL infiltration in tumors for anticancer immunotherapy. The S-LFO treatment promoted tumor vessel normalization, eliminated components of tumor stroma, increased the number of CD3(+)CD8(+) T cells, and facilitated their trafficking to cancer cell regions in tumors. Additionally, the combination of S-LFO with an antiprogrammed death ligand-1 showed therapeutic benefits of retarded tumor growth and extended survivals in three murine tumor models.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

The Development of Chiral Nanoparticles to Target NK Cells and CD8+ T Cells for Cancer Immunotherapy

Weiwei Wang et al.

Summary: This study discovers the potential of chiral nanomaterials as immunoadjuvants for the prevention and treatment of cancer. Chiral nanoparticles enhance immune response and inhibit tumor growth through the stimulation of specific cell types, showing better therapeutic effects compared to achiral nanoparticles.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Hybrid-Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief

Lin Hou et al.

Summary: This study successfully addresses the limitations of tumor-associated macrophages and hypoxia conditions in cancer immunotherapy by developing a hollow mesoporous Prussian blue nanosystem with mannose decoration and hydroxychloroquine adsorption. In vivo experiments demonstrate that this system effectively inhibits tumor growth, induces macrophage polarization, promotes cytotoxic T lymphocytes infiltration, and alleviates hypoxia microenvironment.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Immune-regulating bimetallic metal-organic framework nanoparticles designed for cancer immunotherapy

Zan Dai et al.

Summary: This study successfully synthesized a bimetallic metal-organic framework nanoparticle that can downregulate immunosuppressive signals and upregulate immunostimulatory signals, thus improving the efficacy of cancer immunotherapy.

BIOMATERIALS (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Review Chemistry, Multidisciplinary

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

Sajal Sen et al.

Summary: Cancer is the second deadliest disease worldwide, and immunotherapy using immunogenic cell death (ICD) shows promise in overcoming treatment limitations. Metal-based complexes have been identified as potential ICD inducers. This review assesses the progress in this field and sets the stage for future advances.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Oncology

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Nisha Kumari et al.

Summary: Cancer immunotherapy has had limited success, but nanoparticles have emerged as crucial tools in targeting tumor-associated macrophages (TAMs) and improving therapy outcomes. Current strategies include restricting TAMs survival, inhibiting TAMs recruitment, and repolarizing tumor-supportive TAMs to an antitumor phenotype.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Biochemistry & Molecular Biology

NIR light-controlled mitochondria-targeted delivery of carbon monoxide combined with histone deacetylase inhibition for synergistic anticancer therapy

Qi Tang et al.

Summary: The study synthesized a multifunctional nanoplatform capable of inhibiting histone deacetylases and releasing carbon monoxide to destroy mitochondria, inducing apoptosis in cancer cells. This targeted subcellular delivery of CO combined with inhibitory HDAC activity maximized the cytotoxicity of the nanoplatform, providing new insights into CO-mediated multimodal cancer treatment.

JOURNAL OF INORGANIC BIOCHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Lisi Xie et al.

Summary: In this study, phototheranostic metal-phenolic networks were engineered for precise photo thermal therapy. This therapy could relieve exosomal suppression, restore T cells, and enhance ferroptosis. The synergy of photo thermal therapy with antiexosomal PD-L1 evoked potent antitumor immunity and immunological memory against metastatic tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Copper-Based Metal-Organic Framework Overcomes CancerChemoresistance through Systemically Disrupting DynamicallyBalanced Cellular Redox Homeostasis

Jia Liu et al.

Summary: This study presents a copper/catechol-based metal-organic framework that disrupts the redox homeostasis in drug-resistant cancer cells, leading to increased cellular oxidative stress and selective cytotoxicity. The framework effectively inhibits in vivo drug-resistant tumor growth and improves survival rates in tumor-bearing mice.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Multidisciplinary Sciences

Enantiomer-dependent immunological response to chiral nanoparticles

Liguang Xu et al.

Summary: The study explores the effects of chiral inorganic nanoparticles on complex biochemical networks and finds that different chiral nanoparticles have varying immune responses in vitro and in vivo. Nanoscale chirality can regulate the maturation of immune cells and left-handed nanoparticles show higher efficiency as adjuvants for vaccination.

NATURE (2022)

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Review Immunology

Immunogenic cell stress and death

Guido Kroemer et al.

Summary: Immunogenic cell death (ICD) plays an important role in therapy and disease, as dying mammalian cells release signals that interact with the host to determine the immunological correlates of cellular stress and death. ICD is crucial in immunosurveillance and is related to strategies evolved by pathogens and cancer cells. Additionally, normal cell death can also initiate antigen-specific immune responses.

NATURE IMMUNOLOGY (2022)

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Article Immunology

Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation

Lei Zhou et al.

Summary: Group 3 innate lymphoid cells (ILC3s) protect the intestine from TNF-induced cell death by producing heparin-binding epidermal growth factor-like growth factor (HB-EGF), thereby playing a crucial role in inflammatory bowel disease (IBD).

NATURE IMMUNOLOGY (2022)

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Article Spectroscopy

A turn-on fluorescence sensor for rapid sensing of ATP based on luminescence resonance energy transfer between upconversion nanoparticles and Cy3 in vivo or vitro

Jing Xu et al.

Summary: This study synthesized a Cy3-aptamer-cDNA-UCNPs nanosensor for monitoring ATP in living cells, demonstrating selective sensing ability and linear response to ATP levels with optimization of conditions. The UCNPs sensor showed favorable biocompatibility and potential for fluorescence-mediated imaging and quantitative analysis of intracellular ATP.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Multidisciplinary

Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy

Nailin Yang et al.

Summary: Gas therapy using upconversion nanoparticles (UCNPs) for controlled gas release has shown great promise in various medical applications, such as cancer therapy and bacterial therapy. The unique upconversion luminescence (UCL) ability of UCNPs enables the conversion of long wavelength light to ultraviolet/visible (UV/Vis) light for precise gas release. Further research and development in this area are needed to explore the full potential of UCNP-based nanocomposites in gas therapy.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Changyu Cao et al.

Summary: Utilizing Fenton chemistry in the tumor microenvironment for chemodynamic therapy has shown promising anticancer effects, generating cytotoxic hydroxyl radicals. However, challenges remain in optimizing the treatment efficiency due to limited catalytic efficiency of CDT agents and strong cancer antioxidant capacity in TME. Scientists are working on designing more active CDT agents and remodeling TME for optimal CDT.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

DNA aptamer-based dual-responsive nanoplatform for targeted MRI and combination therapy for cancer

Mingming Zhao et al.

Summary: In this study, a glutathione and adenosine-5'-triphosphate dual-sensitive nanoplatform was fabricated for controlled drug release and activatable MRI of tumors. The nanoplatform, based on DNA aptamer and manganese dioxide nanosheets, allowed targeted drug delivery to tumor cells and on-demand drug release through the co-effect of ATP aptamer and GSH reduction. The combination of MRI and chemodynamic therapy improved the inhibition of tumor growth and imaging.

RSC ADVANCES (2022)

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Review Medicine, Research & Experimental

Targeting regulated cell death in tumor nanomedicines

Qinghu Zeng et al.

Summary: Nanomedicines have great potential in anticancer therapy, but they are limited by self-protection mechanisms and treatment resistance of cancer cells. Recent studies have shown that regulating cell death can enhance the therapeutic efficiency of tumors. This article introduces various strategies of regulated cell death-mediated synergistic tumor nanotherapeutics and discusses the coordination mechanisms.

THERANOSTICS (2022)

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Article Engineering, Biomedical

Anti-PD-L1 DNAzyme Loaded Photothermal Mn2+/Fe3+ Hybrid Metal-Phenolic Networks for Cyclically Amplified Tumor Ferroptosis-Immunotherapy

Peng Liu et al.

Summary: This study develops a metal-phenolic networks (MPNs) nanoplatform for synergistic ferroptosis-immunotherapy cyclical treatment of tumors. By combining photothermal therapy and PD-L1 pathway regulation, a self-amplified tumor treatment strategy is successfully achieved.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Materials Science, Biomaterials

MnO2 coated nanotheranostic LDH for synergistic cascade chemo/chemodynamic cancer therapy under the guidance of MRI-targeted diagnosis

Bengao Zhu et al.

Summary: This study developed an innovative LDH/5-FU@MnO2 nanodrug, combining CT/CDT and MRI for synergistic diagnosis and enhanced anti-tumor efficacy. By converting MnO2 into Mn2+ and utilizing the tumor acidic environment to trigger 5-FU release, this nanomedicine shows promising therapeutic potential in persistent TME modulation and efficient anticancer theranostic performance.

BIOMATERIALS SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Acid-Degradable Hydrogen-Generating Metal-Organic Framework for Overcoming Cancer Resistance/Metastasis and Off-Target Side Effects

Xianxian Yao et al.

Summary: The development of stimuli-responsively degradable porous carriers for controlled drug release is important for clinical translation. In this study, a new type of Fe-MOF nanocrystals is engineered as an acid-degradable drug carrier and hydrogen donor. Fe-MOF nanocrystals exhibit acid-responsive degradation for H-2 generation and simultaneous drug release, and can effectively inhibit cancer metastasis and sensitize MDR cancer cells for enhanced chemotherapy. The high anti-MDR/antimetastasis efficacies and biocompatibility make Fe-MOF nanocrystals and Fe-MOF-based nanomedicine highly promising for clinical translation.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy

Fei Gong et al.

Summary: In this study, CaH2 nanoparticles were prepared through liquid-phase exfoliation and used as an antitumor therapeutic agent. When injected into the tumor, the nano-CaH2 reacts with water to produce hydrogen gas, calcium ions, and hydroxyl ions, which enable hydrogen therapy, tumor calcification, and neutralization of the acidic tumor microenvironment. The results showed that the injectable nano-CaH2 dispersion significantly inhibited tumor growth and activated the immune system to promote immune cell infiltration into the tumor, resulting in robust immune responses to inhibit distant tumors. Furthermore, nano-CaH2 dispersed in lipiodol showed improved therapeutic outcomes in interventional transarterial embolization therapy compared to lipiodol alone in a liver cancer model.

CHEM (2022)

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Article Chemistry, Multidisciplinary

Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

Feng Wu et al.

Summary: The nanomedicine developed in this study integrates nanocarriers and clinical drugs, exhibiting peroxidase mimicking activities and depleting glutathione in the tumor microenvironment, promoting reactive oxygen species-mediated tumor catalytic therapy, and restoring the chemical sensitivity of oxaliplatin, playing an important role in apoptosis and ferroptosis of tumor cells.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy

Wei Jiang et al.

Summary: The study shows that the gaseous molecule nitric oxide (NO) can induce immunogenic cell death (ICD) in tumor cells, triggering a protective immune response.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Smart PdH@MnO2 Yolk-Shell Nanostructures for Spatiotemporally Synchronous Targeted Hydrogen Delivery and Oxygen-Elevated Phototherapy of Melanoma

Wandong Wang et al.

Summary: Hydrogen therapy is an emerging therapeutic strategy in anticancer medicine, but the challenges of stable hydrogen storage and efficient delivery hinder its development. In this study, a smart yolk-shell nanoplatform was designed to overcome these challenges and enhance the efficacy of photodynamic therapy through hydrogen release, increased reactive oxygen species generation, and ameliorated hypoxic conditions.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Self-Enhanced Acoustic Impedance Difference Strategy for Detecting the Acidic Tumor Microenvironment

Xianfu Meng et al.

Summary: B-mode ultrasound imaging is an important technique for anatomical imaging in clinic, but lacks the ability to evaluate organ function and display physiological information. This study proposes a strategy based on self-enhanced acoustic impedance difference to monitor acidic tumor microenvironment. The results show that this method can effectively discriminate different pH regions and is not affected by pressure interference.

ACS NANO (2022)

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Review Pharmacology & Pharmacy

Nanovaccines with cell-derived components for cancer immunotherapy

Zhouqi Meng et al.

Summary: This review article explores the recent research progress of cell-derived biomimetic nanovaccines for cancer immunotherapy, and discusses the perspectives and challenges associated with the future clinical translation of these emerging vaccine platforms.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Boosting Tumor Immunotherapy by Bioactive Nanoparticles via Ca2+ Interference Mediated TME Reprogramming and Specific PD-L1 Depletion

Jingyi An et al.

Summary: This study proposes a previously unknown strategy to enhance the clinical efficacy of PD-1/PD-L1 blockade by re-educating tumor-associated macrophages and depleting PD-L1 through calcium interference. The nanosystem developed in this study demonstrates the ability to inhibit tumor progression, prevent metastasis, and provide long-term immunological memory.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Blocking Cancer-Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain

Xu Chu et al.

Summary: The interaction between tumors and neurons can promote the rapid growth of both, offering new therapeutic targets for cancer treatment. The study proposes a strategy for blocking nerve-cancer crosstalk using Mg/Al layered-double-hydroxide nanoshells and alendronate in the treatment of metastatic bone cancer pain.

ADVANCED MATERIALS (2022)

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Article Chemistry, Analytical

Activatable Nanoprobe with Aggregation-Induced Dual Fluorescence and Photoacoustic Signal Enhancement for Tumor Precision Imaging and Radiotherapy

Meng Yuan et al.

Summary: In this study, a new nanoprobe was developed for tumor FL and PA imaging. The nanoprobe provided complementary visualization and quantifiable information in deeper tissues. Moreover, it also had the capability for radiotherapy. The nanoprobe not only enhanced the FL and PA signals, but also enabled imaging of various biomarkers, benefiting precise cancer therapy.

ANALYTICAL CHEMISTRY (2022)

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Article Engineering, Biomedical

Disruption of dual homeostasis by a metal-organic framework nanoreactor for ferroptosis-based immunotherapy of tumor

Kai Zhang et al.

BIOMATERIALS (2022)

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Review Biochemistry & Molecular Biology

Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity

Lei Shi et al.

Summary: Ferroptosis, a newly described form of regulated cell death, plays a crucial role in immune regulation and anti-tumor therapy by releasing DAMPs and lipid metabolites to modulate cellular immune responses and interacting with immune checkpoint inhibitor therapy.

FEBS JOURNAL (2022)

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Article Engineering, Environmental

Activatable autophagy inhibition-primed chemodynamic therapy via targeted sandwich-like two-dimensional nanosheets

Hongshuai Wu et al.

Summary: The research focuses on the construction of transition metal-containing nanomaterials for chemodynamic therapy. The developed sandwich-like nanosheets showed potential for targeted autophagy inhibition-primed therapy.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Engineering, Environmental

Synthesis, bioactive properties, and biomedical applications of intrinsically therapeutic nanoparticles for disease treatment

Duc Dung Nguyen et al.

Summary: ITNPs are a special class of nanomaterials with intrinsic therapeutic capabilities, which can be utilized to treat diseases associated with oxidative stress, inflammation, angiogenesis, and infection. Recent advancements in the field of nanotherapeutics have been significantly influenced by ITNPs.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

Copper coordinated nanozyme-assisted photodynamic therapy for potentiating PD-1 blockade through amplifying oxidative stress

Guanghui Hou et al.

Summary: The copper nanozyme-assisted photodynamic therapy (PDT) nanoplatform nHACI is developed to efficiently induce immunogenic tumor cell death (ICD) and robust systemic antitumor immune response through increased intracellular oxidative stress. The nHACI exhibits superior drug loading efficiency, tumor microenvironment-responsive degradation behavior, and triple activities. The combination of nHACI-based PDT and PD-1 blockade can efficiently eradicate primary tumors, inhibit distant tumor growth and lung metastasis, and prevent tumor recurrence.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Multidisciplinary

Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Yongchao Liu et al.

Summary: Photoacoustic imaging technology combines the advantages of optical and acoustic imaging, offering high imaging depth and resolution for molecular imaging. Activatable molecular PA probes show promise for real-time molecular visualization and precise biomedical diagnosis. These probes can alter their PA intensities upon reacting with specific targets or biological events, providing new possibilities for biomedical applications.

CHEMICAL REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Low Colorectal Tumor Removal by E-Cadherin Destruction-Enabled Tumor Cell Dissociation

Man Li et al.

Summary: In this study, a highly effective and safe treatment modality for low colorectal cancer was verified, which involved tumor cell dissociation and removal through the release of EDTA and subsequent defecation, providing a new therapeutic approach for patients suffering from low colorectal cancer.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Degradable Magnetic Nanoplatform with Hydroxide Ions Triggered Photoacoustic, MR Imaging, and Photothermal Conversion for Precise Cancer Theranostic

Yudan Yang et al.

Summary: Theranostic agents based on magnetic ions coordinated nanoplatform show excellent multimodal imaging and photothermal therapy effects in tumors, providing a potential application for cancer treatment.

NANO LETTERS (2022)

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Article Chemistry, Physical

Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy

Mengyu Sun et al.

Summary: A nanozyme-based NO generator, cerium oxide (CeO2)-AT, has been developed to selectively produce nitric oxide (NO) in cancer cells for tumor treatment. The generator can disrupt the mitochondrial respiratory chain of tumor cells and induce cell apoptosis by catalyzing the production of NO in the mitochondria of cancer cells. Furthermore, the generator can improve the performance of NO gas therapy by catalyzing H2O2 to produce O-2. This study provides a new approach for safe and specific cancer therapy using highly selective NO-based treatment.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy

Hao Tian et al.

Summary: A phenolic nanoadjuvant has been developed to enhance the maturation of dendritic cells (DCs) and improve the efficacy of cancer immunotherapy. This nanoadjuvant promotes the activation of the cGAS-STING pathway and sensitizes tumors to PD-L1 checkpoint blockade immunotherapy, resulting in inhibiting tumor growth and restraining lung metastasis.

NANO TODAY (2022)

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Article Chemistry, Multidisciplinary

Bioinspired magnetic nanocomplexes amplifying STING activation of tumor-associated macrophages to potentiate cancer immunotherapy

Tianliang Li et al.

Summary: This study developed bioinspired magnetic nanocomplexes to enhance antitumor immunogenicity by amplifying the STING-regulated immune cascade of TAMs. The nanocomplexes specifically accumulated at the tumor site and repolarized TAMs into antitumor M1 phenotype, leading to activation of the STING pathway and priming of tumor-specific CTLs. In combination with immune checkpoint blockade therapy, the nanocomplexes effectively inhibited tumor growth and prolonged survival in mouse models, providing new insights for cancer immunotherapy.

NANO TODAY (2022)

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Article Chemistry, Multidisciplinary

Tumor-targeted biocatalyst with self-accelerated cascade reactions for enhanced synergistic starvation and photodynamic therapy

Xuan Gao et al.

Summary: This study presents a multi-layered porous biocatalyst (USCGP) that enables cascade reactions-enhanced synergistic cancer therapy. By loading glucose oxidase (GOD) for glucose decomposition and tumor microenvironment regulation, as well as cascade reactions and photodynamic therapy, USCGP demonstrates effective tumor suppression and imaging capabilities for tumor diagnosis.

NANO TODAY (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy

Yang Zhu et al.

Summary: In this study, a self-supply oxygen photodynamic nanomedicine system was constructed, which achieved tumor therapy by modulating the tumor microenvironment. This nanomedicine exhibited small size and high stability, leading to pronounced accumulation in the tumor, decreased expression of hypoxia-inducible factor, enhanced anti-tumor efficacy, and improved MRI imaging in the tumor.

SMALL (2022)

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Article Multidisciplinary Sciences

Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth

Nailin Yang et al.

Summary: The researchers developed magnesium galvanic rods that continuously produce hydrogen and found that hydrogen can be used as an anti-cancer treatment. By implanting these rods into tumors, hydrogen molecules can be generated within the tumor, leading to tumor inhibition. This hydrogen therapy based on implantable metals may be a safe and effective cancer treatment.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy

Shan Lei et al.

Summary: The study demonstrates the use of three-dimensional multispectral photoacoustic molecular imaging to monitor cascade catalytic therapy in vivo, and shows its potential application in tumor treatment.

NATURE COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

Perfluorooctyl bromide nanoemulsions holding MnO2 nanoparticles with dual-modality imaging and glutathione depletion enhanced HIFU-eliciting tumor immunogenic cell death

Xinping Kuai et al.

Summary: This study developed an innovative platform for tumor-targeted immunotherapy using nanoemulsions and nanoparticles, which can regulate the tumor immune microenvironment to inhibit tumor growth and metastasis. This finding has significant clinical implications.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Biochemistry & Molecular Biology

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Weitong Gao et al.

Summary: Immunotherapy has made significant breakthroughs in cancer treatment, but the poor response of some tumors limits its application. Inducing non-apoptotic regulated cell death (RCD) may convert these unresponsive tumors into those that respond to immunotherapy. Autophagy, ferroptosis, pyroptosis, and necroptosis have been found to have both inhibitory and synergistic effects on antitumor immune responses, suggesting that targeted therapies against these processes combined with immunotherapy may be effective even in resistant tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Chemistry, Multidisciplinary

MnO2 nanosheets as a carrier and accelerator for improved live-cell biosensing application of CRISPR/Cas12a

Dong-Xia Wang et al.

Summary: This study demonstrates that MnO2 nanosheets are an excellent carrier for the CRISPR/Cas12a system, enabling efficient delivery and rapid release in living cells. The use of MnO2 nanosheets improves the performance of live-cell biosensing analysis compared to commercial carriers.

CHEMICAL SCIENCE (2022)

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Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

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Article Nanoscience & Nanotechnology

Efficient Magnetic Nanocatalyst-Induced Chemo- and Ferroptosis Synergistic Cancer Therapy in Combination with T-1-T-2 Dual-Mode Magnetic Resonance Imaging Through Doxorubicin Delivery

Ling Zhu et al.

Summary: A novel magnetic nanocatalyst was developed for MRI-guided chemo- and ferroptosis synergistic cancer therapies, releasing abundant Fe(II) ions to induce oxidative stress and promote ferroptosis.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Oncology

Prospective of nanoscale metal organic frameworks [NMOFs] for cancer therapy

Mohammed Razeeth Shait Mohammed et al.

Summary: Nano metal organic frameworks (NMOFs) are a type of nanoporous materials with excellent physico-chemical features. Researchers have been exploring the potential use of NMOFs in cancer diagnosis and therapeutics. Despite significant research done, more information regarding the stability, in-vivo clearance, toxicology, and pharmacokinetics of NMOFs in cancer diagnostic and therapeutic applications is still needed.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Chemistry, Multidisciplinary

Challenges and Opportunities in Cancer Drug Resistance

Richard A. Ward et al.

Summary: Recent years have seen significant progress in targeted cancer therapies, but drug resistance remains a common challenge. Researchers are exploring new approaches to overcome resistance, such as increasing drug selectivity and potency, using alternative chemical structures, changing mechanisms of action, and targeting allosteric pockets.

CHEMICAL REVIEWS (2021)

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Article Multidisciplinary Sciences

Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors

Nailin Yang et al.

Summary: Magnetic hyperthermia therapy using magnesium alloy for tumor ablation demonstrates effective results both in vitro and in vivo, showing strong heating performance and excellent biocompatibility. This non-magnetic biodegradable material could be a promising candidate for clinical applications in tumor treatment.

NATIONAL SCIENCE REVIEW (2021)

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Review Engineering, Biomedical

Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

Zachary T. Rosenkrans et al.

Summary: Advancements in technology and nanomedicine have led to the development of nanoparticles capable of multimodal imaging with internal stimulus response, improving image contrast for cancer detection. By utilizing stimuli within the tumor microenvironment, such as pH gradients and enzyme overproduction, these nanomaterials can enhance imaging capabilities effectively.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles

Jing Wang et al.

Summary: The translational success of liposomes in chemotherapeutics has shown the potential of biomembrane-based nanostructures in drug delivery, while efforts are also being made in utilizing naturally derived lipid membranes for anti-cancer therapies. Despite differences in production and composition, the common phospholipid bilayer structure allows for modification and functionalization of liposomes, cell membrane-derived nanomaterials, and extracellular vesicles to combat challenges in tumor-targeted drug delivery. The review summarizes recent advancements in engineering membrane-derived nanostructures with intelligent modules for targeting tumor cells and the microenvironment in fighting malignancy, and discusses the potential of enhancing cancer therapy by combining engineered functionalities with naturally occurring activity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

ZnS@BSA Nanoclusters Potentiate Efficacy of Cancer Immunotherapy

Dong Cen et al.

Summary: This study demonstrated that ZnS@BSA nanoclusters, synthesized through a self-assembly approach, significantly enhance cGAS/STING signals by releasing zinc ions in the acidic tumor microenvironment, leading to improved immunotherapy efficacy against hepatocellular carcinoma.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Activatable NIR-II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

Chunyu Zhou et al.

Summary: The study presents a transformable chain structure based on gold nanochains that can be activated in the tumor microenvironment, exhibiting strong NIR-II absorption and excellent properties for tumor treatment.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment

Xiao Fang et al.

Summary: The study introduces a NO-based phototherapeutic strategy for hypoxic tumors using photogenerated holes to oxidize water into H2O2, subsequently producing NO. In vitro and in vivo experiments demonstrated that this strategy induced cancer cell apoptosis, paving the way for the development of NO therapeutic strategies.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Multifunctional carbon monoxide nanogenerator as immunogenic cell death drugs with enhanced antitumor immunity and antimetastatic effect

Xiao Xiao et al.

Summary: This study discusses the use of CO gas therapy to enhance anti-tumor immunity, integrating gas therapy and immunotherapy into a photocatalytic nanogenerator. The approach effectively induces immunogenic cell death (ICD), boosts immune responses, and activates immune cells, leading to an enhanced immune effect when combined with Immune Checkpoint Blockade (ICB). This in-situ photocatalytic CO therapy strategy avoids toxicity from CO leakage and offers a new method for designing novel ICD inducers.

BIOMATERIALS (2021)

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Article Pharmacology & Pharmacy

Lipid-encapsulated upconversion nanoparticle for near-infrared light-mediated carbon monoxide release for cancer gas therapy

Yaw Opoku-Damoah et al.

Summary: The research developed a versatile nanosystem capable of delivering carbon monoxide gasotransmitter in the form of a photo-responsive carbon monoxide-releasing molecule for targeted cancer therapy. The synthesized delivery system showed efficient release of CO upon near infrared light excitation, leading to cytotoxicity in cancer cells through ROS production and cell apoptosis. Therefore, the study highlights the potential of an NIR-mediated UCNP-based CORM prodrug delivery system for targeted cancer gas therapy.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Article Engineering, Environmental

Remodeling endogenous H2S microenvironment in colon cancer to enhance chemodynamic therapy

Donglin Liu et al.

Summary: Chemodynamic therapy (CDT) is a minimally invasive treatment with high selectivity and promising clinical application, but it lacks effectiveness in inhibiting the growth of colon cancer due to the strongly reducing tumor microenvironment. A new strategy utilizing CuFe2O4 nanoparticles to deplete endogenous H2S and enhance CDT has been proposed, showing significant synergistic effects on improving the performance of CDT for colon cancer.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor

Huige Zhou et al.

Summary: Hypoxia is common in solid tumors and affects tumor response to therapy. Understanding tumor hypoxia distribution is crucial for personalized treatment. A novel hypoxia imaging probe provides dual-mode imaging in vivo, enhancing detection of hypoxic regions in solid tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Review Cell Biology

Aluminium adjuvants in vaccines-A way to modulate the immune response

Ravi Danielsson et al.

Summary: Aluminium salts have been used in vaccines as adjuvants for almost a century, but the mechanisms behind the immune stimulating properties are still not fully understood. A persistent intracellular presence of aluminium ions over an extended time may affect the functionality of sentinel cells of the innate immune system, inducing polarization and activation. The immune stimulating properties of aluminium adjuvants are presumably mediated by several discrete events, with a persistent intracellular presence of aluminium ions being a key factor.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

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Article Nanoscience & Nanotechnology

Nitroreductase-Induced Aggregation of Gold Nanoparticles for Off-On Photoacoustic Imaging of Tumor Hypoxia

Xin Li et al.

Summary: Hypoxia-responsive gold nanoparticles were designed as a potential diagnostic agent for precise cancer treatment, showing enhanced photoacoustic signal in hypoxic conditions through aggregation and spectral shift.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Alexander B. Cook et al.

Summary: Materials that respond to endogenous stimuli play a crucial role in enhancing spatiotemporal control in biomedical applications. These materials can be designed to undergo morphological or chemical changes in response to specific biological cues, offering promising opportunities for improving therapeutic efficacy and developing personalized healthcare systems. They can be engineered across different length scales to respond to endogenous signals such as enzymes, pH, glucose, and hold great potential for a wide range of applications.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

An Acidity-Unlocked Magnetic Nanoplatform Enables Self-Boosting ROS Generation through Upregulation of Lactate for Imaging-Guided Highly Specific Chemodynamic Therapy

Linan Shi et al.

Summary: A novel nanoplatform was developed in this study, which can achieve high-efficient tumor-specific catalytic anticancer treatment in acidic tumor microenvironments through a cyclic amplification strategy, leading to enhanced Fenton-like reaction. Ultimately, this smart nanoplatform enables self-boosting generation of reactive oxygen species (ROS), inducing strong intracellular oxidative stress, and resulting in substantial anticancer outcomes in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Biophysics

Advances in inorganic-based colloidal nanovehicles functionalized for nitric oxide delivery

Lianjiang Tan et al.

Summary: The review highlights the development of functionalized colloidal nanovehicles for NO delivery, utilizing various nanomaterials as carriers for NO donors to achieve controlled NO release. These nanovehicles hold great potential in various therapeutic applications, including cancer therapy.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Chemistry, Inorganic & Nuclear

Titanium-based nanomaterials for cancer theranostics

Xianwen Wang et al.

Summary: Research on titanium-based nanomaterials has expanded to the field of biomedicine, showing potential in cancer theranostics by offering versatile platforms for multiple therapies and imaging techniques. Combination therapy with titanium-based nanomaterials has been effective in enhancing therapeutic outcomes and reducing side effects.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

Binbin Ding et al.

Summary: This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy, which can release ions to induce intracellular osmotic imbalance and trigger cell death mechanisms. In vivo tests confirm that ZrNPs-induced pyroptosis exhibits superior antitumor immunity activity, inhibiting tumor growth and pulmonary metastasis.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects

Changlong Wang et al.

Summary: Trivalent arsenic (As-III) is effective in treating acute promyelocytic leukemia, but its limitations include low effective concentrations in leukemia cells and off-target cytotoxicity. Researchers designed a ferritin-based As nanomedicine, As@Fn, that targets leukemia cells expressing CD71 with high affinity, demonstrating improved efficacy in different leukemia types in animal models.

NATURE NANOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy

Xiaoqi Sun et al.

Summary: Metalloimmunotherapy utilizes metal ions to amplify the anti-tumour immune response promoted by STING agonists, forming nanoparticles that effectively deliver STING agonists and achieve remarkable therapeutic efficacy in multiple tumour models. This work highlights the great potential of coordination nanomedicine for metalloimmunotherapy.

NATURE NANOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

Mingjing Cao et al.

Summary: Understanding the in vivo biotransformation of nanomaterials, such as molybdenum derived from MoS2, can shed light on their long-term effects on liver metabolism. Through a combination of in vivo experiments and molecular dynamics simulations, the study reveals that the biodistribution of molybdenum is mediated by protein coronas, mainly with apolipoprotein E, leading to increased enzyme activities in the liver. The findings suggest that nanomaterials consisting of essential trace elements may be converted into active biological molecules in organisms.

NATURE NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

Guohao Wang et al.

Summary: This study reveals the ability of exosomal PD-L1 to inhibit T cell activity and confer resistance to immune checkpoint blockade therapy. By combining an exosome inhibitor and a ferroptosis inducer in a nanotherapy, the response to anti-tumor immune responses is enhanced, particularly in the context of PD-L1 checkpoint blockade.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis

Hao Li et al.

Summary: A nanoprobe based on NIR-IIb emitting quantum dots was designed to alleviate hypoxia in the tumor microenvironment, enhancing precision and efficacy of radiotherapy, and promoting anti-tumor immune responses.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis

Jiacai Yang et al.

Summary: This study presents an intriguing nanomedicine strategy for achieving autophagy-enhanced ferroptosis in cancer therapy. The construction of trehalose-loaded mSiO(2)@MnOx-mPEG nanoparticles allowed for the induction of cancer-cell ferroptosis by deactivating GPX4 and subsequent autophagy by trehalose release, leading to a substantial antitumor effect in vitro and in vivo.

SCIENCE BULLETIN (2021)

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Article Nanoscience & Nanotechnology

Anti-Tumor Metastasis via Platelet Inhibitor Combined with Photothermal Therapy under Activatable Fluorescence/Magnetic Resonance Bimodal Imaging Guidance

Xu Zhang et al.

Summary: A multi-stimuli-responsive nanosystem was developed for targeted photothermal therapy of tumors, with features including pH/reduction/NIR light-responsive drug release. The system showed significant anticancer efficacy in experiments, resulting in ablation of primary tumor cells and effective suppression of distant metastasis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Metal-Organic Frameworks Enhance Biomimetic Cascade Catalysis for Biosensing

Weiqing Xu et al.

Summary: Biological cascade catalysis involving multiple enzymes guides efficient and selective substrate transformations in vivo, with MOFs and nanozymes being widely used to enhance enzyme stability. Breakthroughs have been made in sensitive detection of various targets through diverse signal output modes, demonstrating the potential of MOFs in cascade reaction systems.

ADVANCED MATERIALS (2021)

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Article Chemistry, Analytical

Two-Photon CQDs-Based Dual-Mode Nanoprobe for Fluorescence Imaging and Magnetic Resonance Imaging of Intracellular Wide pH

Hongmei Zhong et al.

Summary: Dual-mode imaging, combining TP fluorescence imaging and MRI, shows promise in improving accuracy for early disease diagnosis, especially in pH-related diagnosis and treatment, with great potential to enhance clinical efficacy.

ANALYTICAL CHEMISTRY (2021)

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Article Biotechnology & Applied Microbiology

Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer

Xiang Pan et al.

Summary: In colorectal cancer, the excessive concentration of H2S can be effectively reduced by a zinc oxide coated virus-like silica nanoparticles (VZnO), leading to tumor inhibition through activating ferroptosis. This nanoplatform shows low toxicity and high safety in colorectal cancer treatment, and does not have therapeutic effects on other non H2S rich cancers.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Intrinsic nucleus-targeted ultra-small metal-organic framework for the type I sonodynamic treatment of orthotopic pancreatic carcinoma

Tao Zhang et al.

Summary: The nucleus-targeted ultra-small Ti-TCPP MOF developed in this study represents an effective approach to enhanced SDT treatment of tumors in response to low-intensity US irradiation. This MOF showed promising therapeutic efficacy by inducing cell apoptosis and inhibiting orthotopic pancreatic tumor growth, without apparent toxicity, suggesting its potential for clinical applications.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Engineered Cell Membrane-Derived Nanoparticles in Immune Modulation

Yixiao Yang et al.

Summary: Immune modulation using cell membrane-derived nanoparticles (CMDNs) is an effective approach for treating complex diseases, improving treatment efficacy by leveraging the cell membrane's components. The shift from natural to engineered cell membranes in CMDNs is enhancing their potential for precise immune system control.

ADVANCED SCIENCE (2021)

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Article Materials Science, Multidisciplinary

P-glycoprotein suppression by photothermal-responsive nitric oxide releasing nanoplatform for triple-combination therapy of multidrug resistant cancer

Youyou Huang et al.

Summary: A novel nanoplatform was designed for reversing drug resistance in multi-drug resistant cells by releasing nitric oxide (NO) gas triggered by photothermal conversion, which could induce mitochondrial dysfunction and overcome multi-drug resistance. This system holds potential as an effective strategy against drug resistance and may provide new insights for other medical applications related to NO gas.

MATERIALS & DESIGN (2021)

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Review Oncology

Nanozymes in Tumor Theranostics

Qiulian Ma et al.

Summary: Nanozymes, a new generation of enzyme mimics, have shown great advancements in tumor biology, displaying high-efficiency catalytic activities under mild conditions and overcoming the limitations of natural enzymes.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al.

Summary: Pyroptosis is an inflammatory form of cell death with tumor suppressive function and the ability to evoke anti-tumor immune responses. Cancer therapies induce pyroptosis, enhancing anti-tumor immunity, but also leading to side effects on normal cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Materials Science, Multidisciplinary

Titanium-based sonosensitizers for sonodynamic cancer therapy

YuqiD Yang et al.

Summary: Sonodynamic therapy is a new cancer treatment strategy that uses ultrasound to trigger sonosensitizers to produce reactive oxygen species to kill malignant tumors. Titanium-based nanomaterials, particularly TiO2, are high-efficiency sonosensitizers with unique physicochemical properties widely applied in SDT.

APPLIED MATERIALS TODAY (2021)

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Review Nanoscience & Nanotechnology

Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer

Sinan Sabuncu et al.

Summary: Ultrasound has long been used in the clinic for cancer detection and therapy, with stabilized fluorocarbon microbubbles as contrast agents. However, the limitations of microbubbles in terms of size, stability, and cavitation activity have led to the exploration of gas-stabilizing nanoparticles as an alternative material for improved methods in molecular ultrasound imaging and cancer therapy.

NANO CONVERGENCE (2021)

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Article Multidisciplinary Sciences

A tumor microenvironment-induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

Shulong Wang et al.

Summary: The study found that the GSH level significantly increases in tumor tissues, thus it can be used as an endogenous molecule for diagnosing and treating tumors. The Fe-Cu@PANI nanoparticles prepared in the study utilize the tumor microenvironment-induced properties to activate tumor photoacoustic imaging and photothermal therapy in vivo, enhancing the efficiency of treatment.

SCIENCE ADVANCES (2021)

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Review Pharmacology & Pharmacy

New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors

Xu Hu et al.

Summary: Pancreatic cancer is a deadly disease with poor prognosis and resistance to treatments. The gasotransmitter hydrogen sulfide (H2S) has shown potential in modulating cancer development, with exogenous H2S donors being considered as promising compounds for pancreatic cancer therapy.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Physics, Multidisciplinary

Acoustically-Stimulated Nanobubbles: Opportunities in Medical Ultrasound Imaging and Therapy

Brandon Helfield et al.

Summary: Medical ultrasound is widely used for imaging, with microbubbles serving as contrast agents confined to the vasculature. There is growing interest in developing submicron, nanoscale agents like lipid-encapsulated nanobubbles. These next-generation ultrasound contrast agents have the potential to advance ultrasound diagnostic and therapeutic medicine.

FRONTIERS IN PHYSICS (2021)

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Article Nanoscience & Nanotechnology

GSH-Sensitive Nanoscale Mn3+-Sealed Coordination Particles as Activatable Drug Delivery Systems for Synergistic Photodynamic-Chemo Therapy

Peng Geng et al.

Summary: This study developed a GSH-sensitive NDDS with high biosafety, cancer specificity, and multifunctionality for effective synergistic treatment. By loading doxorubicin in DOX@MnCPs/PEG, the NDDS showed efficient tumor homing and significant suppression of tumor growth in vivo through synergistic photodynamic-chemo therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Boron Nitride Nanosheets Can Induce Water Channels Across Lipid Bilayers Leading to Lysosomal Permeabilization

Matteo Andrea Lucherelli et al.

Summary: The study investigates the interaction between hexagonal boron nitride (hBN) nanosheets of different shapes and cell membranes, finding that sharp-edged hBN can form cross-membrane water channels leading to cellular toxicity, while round hBN does not exhibit this behavior.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Tumor-Microenvironment-Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal-Enhanced Enzyme Dynamic Therapy

Bin Liu et al.

Summary: A rapidly decomposing nanocomposite was designed in this study to improve the efficiency of enzyme dynamic therapy, enhancing tumor therapy through multiple pathways and developing a new treatment strategy.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Smart Nanozyme Platform with Activity-Correlated Ratiometric Molecular Imaging for Predicting Therapeutic Effects

Lili Teng et al.

Summary: A novel nanozyme with oxidase-like activity was developed for acid-induced cancer therapy, utilizing ratiometric near-infrared fluorescence-photoacoustic molecular imaging to report its catalytic activity. The nanozyme showed excellent anticancer efficacy in the tumor microenvironment, and the ratiometric signals provided a new approach for predicting its efficacy in living systems.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Oncology

Pyroptosis, a new bridge to tumor immunity

Lisha Li et al.

Summary: Pyroptosis is a type of programmed cell death that can activate the immune system to kill cancer cells, yet it may also promote tumor development by changing the immune microenvironment.

CANCER SCIENCE (2021)

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Review Chemistry, Inorganic & Nuclear

Photodynamic therapy for hypoxic tumors: Advances and perspectives

Li Huang et al.

Summary: Photodynamic therapy (PDT) is a preferred clinical technology for treating tumors, but the hypoxic tumor microenvironment weakens its efficiency. Strategies for improving PDT efficacy in hypoxic tumors include increasing oxygen concentration, disregarding hypoxia, and exploiting hypoxia. Combining PDT with other therapeutics can also enhance treatment outcomes.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

Rong-Hsuan Wang et al.

Summary: Hydrogen sulfide, while important for physiological functions, is also associated with aberrant expression in cancer development; understanding the roles of tumor-derived H2S in cancer provides opportunities for targeted therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Pyroptosis at the forefront of anticancer immunity

Reid Loveless et al.

Summary: Pyroptosis, a lytic and inflammatory programmed cell death pathway, has shown potential in addressing tumor resistance to apoptosis and the immunosuppressive tumor microenvironment by inducing a robust inflammatory response and marked tumor regression. Gasdermin proteins mediate pyroptosis and facilitate immune cell activation and infiltration, but aberrant pyroptosis may also contribute to tumor progression by upregulating gasdermin proteins in certain cancers. Harnessing pyroptosis as a tool in anticancer strategies shows promise in novel interventions.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy

Huan Liang et al.

Summary: This study synthesized ultrasmall single-crystal Fe nanoparticles that showed high activity in inducing tumor cell ferroptosis and immunogenetic cell death in the tumor microenvironment at a low concentration. These nanoparticles effectively suppressed tumor growth, promoted dendritic cell maturation, and triggered T cell response in animal models, and when combined with immune checkpoint blockade therapy, they greatly enhanced the immune response and developed strong immune memory. Furthermore, the nanoparticles were quickly excreted in the kidneys without side effects in normal tissues.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Nanoscience & Nanotechnology

Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Ximing Shao et al.

Summary: The study reveals a tumoricidal mechanism of black phosphorus nanomaterials where they directly affect the mitotic centrosome machinery by suppressing polo-like kinase 1, suggesting that nanomaterials can be applied in targeted cancer therapy with their intrinsic nano-bio properties.

NATURE NANOTECHNOLOGY (2021)

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Review Nanoscience & Nanotechnology

Environmental dimensions of the protein corona

Korin E. Wheeler et al.

Summary: This review discusses the importance of dynamic protein corona composition in mediating the fate of nanomaterials in the environment, as well as future steps in eco-corona studies. The formation of the biomolecular coating on nanomaterials entering the environment, known as the eco-corona, is still an emerging area of research. Proteins within the eco-corona play a crucial role in defining the biological identity of nanomaterials and their impacts on the environment.

NATURE NANOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Functionalized Tumor-Targeting Nanosheets Exhibiting Fe(II) Overloading and GSH Consumption for Ferroptosis Activation in Liver Tumor

Ke Li et al.

Summary: The study introduces a novel strategy to induce cell death by targeting liver tumor nanosheets in HepG2 cells, demonstrating superior ferroptosis induction ability and anti-tumor efficacy.

SMALL (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis in the tumor microenvironment: perspectives for immunotherapy

Huanji Xu et al.

Summary: Targeting ferroptosis as a new approach for anticancer therapy shows potential as it induces lipid peroxidation in cancer cells. Understanding how immune cells in the tumor microenvironment respond to lethal lipid peroxides may uncover new possibilities for cancer immunotherapy. This study provides an overview of the metabolic processes involved in ferroptosis and explores its roles in cancer immunity, highlighting the potential for targeted therapy.

TRENDS IN MOLECULAR MEDICINE (2021)

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Article Materials Science, Multidisciplinary

Tumor microenvironment/NIR-responsive carbon monoxide delivery with hollow mesoporous CuS nanoparticles for MR imaging guided synergistic therapy

Shaohui Zheng et al.

Summary: A novel versatile carbon monoxide (CO) delivery nanoplatform was constructed in this study for MR imaging-guided PTT and CO combined anticancer therapy, showing excellent therapeutic efficacy and biocompatibility both in vitro and in vivo.

MATERIALS & DESIGN (2021)

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Article Multidisciplinary Sciences

A nonferrous ferroptosis-like strategy for antioxidant inhibition-synergized nanocatalytic tumor therapeutics

Chenyao Wu et al.

Summary: This study introduces a non-ferrous ferroptosis-like strategy based on a hybrid CoMoO4-phosphomolybdic acid nanosheet (CPMNS), which achieves efficient anticancer efficacy through specific mechanisms. The high feasibility of this approach in nanocatalytic medicine is expected to advance cancer therapeutic regimens in the future.

SCIENCE ADVANCES (2021)

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Review Cell Biology

Bioactive Glass: Methods for Assessing Angiogenesis and Osteogenesis

Jos Crush et al.

Summary: Biomaterials play an important role in bone tissue regeneration, especially in cases of trauma, infection, and congenital abnormalities. Bioactive glasses can bond with host bone and induce bone and blood vessel growth, with their composition manipulated to maximize osteogenesis and angiogenesis, providing a structure that resists physiological stresses. Accurate methods for studying and quantifying osteogenesis and angiogenesis in bioactive glass experiments are crucial for identifying potential future clinical applications.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Opportunities for Ferroptosis in Cancer Therapy

Kenji M. Fujihara et al.

Summary: Ferroptosis, a form of cell death characterized by lipid peroxidation and iron accumulation, has shown potential as an alternative therapeutic strategy for destroying tumors. Despite extensive research on its molecular mechanisms, translating this knowledge into clinical compounds remains a challenge. This perspective elaborates on leveraging ferroptosis in the clinic, discussing therapeutic windows, tumor sensitivity, conventional therapeutics, and strategies to enhance ferroptosis.

ANTIOXIDANTS (2021)

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Article Chemistry, Multidisciplinary

Immunogenic cell death inducers for enhanced cancer immunotherapy

Yanhua Li et al.

Summary: The article highlights the importance of inducing immunogenic cell death (ICD) of cancer cells and discusses strategies and inducers to trigger ICD for enhanced cancer immunotherapy. It aims to inspire readers to develop more effective ICD inducers.

CHEMICAL COMMUNICATIONS (2021)

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Article Materials Science, Biomaterials

Fe3O4 assembly for tumor accurate diagnosis by endogenous GSH responsive T2/T1 magnetic relaxation conversion

Chengbin Wang et al.

Summary: The study introduces ultra-small Fe3O4 nanoclusters as an endogenous GSH-responsive MRI contrast agent for improved tumor diagnosis by utilizing the overexpression of GSH in tumors to achieve T-2/T-1 signal switching.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Chemistry, Physical

Colloidal synthesis of Au nanomaterials with a controlled morphology and crystal phase via the [Au(i)-oleylamine] complex

Gang Wang et al.

Summary: This review provides a comprehensive overview of the morphology- and crystal phase-controlled synthesis of gold nanomaterials using the [Au(i)-oleylamine] complex as the intermediate. Various proposed formation mechanisms of different morphologies and crystal phases are discussed, highlighting the uniqueness of the [Au(i)-oleylamine] interaction. Additionally, the applications of oleylamine-capped gold nanomaterials in catalysis and electronic devices are introduced, with perspectives on the challenges and opportunities in this direction.

JOURNAL OF MATERIALS CHEMISTRY A (2021)

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Article Chemistry, Multidisciplinary

Two-dimensional intermetallic PtBi/Pt core/shell nanoplates overcome tumor hypoxia for enhanced cancer therapy

Yongchun Liu et al.

Summary: The study created PtBi/Pt nanoplates to address tumor hypoxia and demonstrated significant enhancement in photothermal/radiotherapy effects. The PEGylated PtBi NPs showed excellent biocompatibility and multimodal contrast enhancement, indicating potential as a novel nanoplatform for future multimodal imaging-guided synergistic cancer therapy.

NANOSCALE (2021)

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Article Chemistry, Inorganic & Nuclear

The pH responsive upconversion fluorescence and photothermal conversion properties of NaYF4:Yb3+/Er3+@NaYF4@MnO2@Au

Xia Xu et al.

Summary: In this study, a pH-responsive upconversion fluorescence imaging-guided photothermal therapy system was successfully developed, which can avoid light damage to non-target tissues and achieve upconversion fluorescence imaging under specific pH conditions.

DALTON TRANSACTIONS (2021)

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Review Chemistry, Multidisciplinary

Inorganic nanomaterials with rapid clearance for biomedical applications

Xianwen Wang et al.

Summary: Inorganic nanomaterials have great potential in biomedicine, but long-term accumulation in healthy tissues can cause toxicity. The emergence of biodegradable and clearable inorganic nanomaterials provides a way to prevent such toxicity, and a comprehensive understanding of their design and metabolic pathways is essential for expanding therapeutic applications for various diseases.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Materials Science, Biomaterials

Metal-phenolic networks for cancer theranostics

Peng Liu et al.

Summary: Metal-phenolic networks (MPNs) have emerged as a promising nanomaterial for cancer theranostics, offering advantages such as excellent biocompatibility, drug loading capabilities, and stimuli-responsive properties. They have been utilized in multimodal tumor therapy and imaging, showcasing great potential in the biomedical field.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic anticancer therapy

Qi Tang et al.

Summary: A multifunctional nanoplatform was developed for mitochondria-targeted carbon monoxide (CO) delivery combined with photodynamic therapy, showing high lethality against cancer cells and good dark biocompatibility with normal cells expressing low H2O2 levels. This work may offer new insights into efficient cancer treatment by combining CO-based gas therapy with traditional PDT.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Mitochondria targeted nanoparticles to generate oxygen and responsive-release of carbon monoxide for enhanced photogas therapy of cancer

Hao Ren et al.

Summary: The study developed human serum albumin nanoparticles combined with manganese dioxide to deliver a CO donor and photosensitizer for a synergistic therapy combining CO gas therapy and phototherapy. By catalyzing hydrogen peroxide to produce oxygen, the nanoparticles enhanced photodynamic therapy and triggered CO release for enhanced gas therapy. The strategy provides a novel approach for cancer treatment by combining phototherapy and CO gas therapy with oxygen generating and thermal-responsive CO release.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy

Zebin Yang et al.

Summary: By developing novel nanoparticles combined with photothermal and gas therapy, tumor growth can be inhibited in the tumor environment, opening up a new approach for the design of gas-mediated cancer treatment.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

2D Nanomaterials for Cancer Theranostic Applications

Liang Cheng et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Analytical

Biodegradable MnO2 nanosheet based DNAzyme-recycling amplification towards: Sensitive detection of intracellular MicroRNAs

Fei Liu et al.

TALANTA (2020)

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Article Chemistry, Analytical

Protein-assisted formation of gold clusters-MnO2 nanocomposite for fluorescence imaging of intracellular glutathione

Yanlin Du et al.

TALANTA (2020)

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Article Engineering, Environmental

In situ photothermal activation of necroptosis potentiates black phosphorus-mediated cancer photo-immunotherapy

Henan Zhao et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Engineered immunogen binding to alum adjuvant enhances humoral immunity

Tyson J. Moyer et al.

NATURE MEDICINE (2020)

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Article Chemistry, Physical

Gas-Generating, pH-Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast-Enhanced Ultrasound Imaging

Mark Louis P. Vidallon et al.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2020)

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Review Pharmacology & Pharmacy

Targeting necroptosis in anticancer therapy: mechanisms and modulators

Ying Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Chemistry, Multidisciplinary

RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells

Xue-lian Zheng et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Review Oncology

Autophagy regulation as a promising approach for improving cancer immunotherapy

Nestor Ishimwe et al.

CANCER LETTERS (2020)

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Article Chemistry, Multidisciplinary

FeS@BSA Nanoclusters to Enable H2S-Amplified ROS-Based Therapy with MRI Guidance

Congkun Xie et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy

Haifeng Yuan et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Mechanistic Differences in Cell Death Responses to Metal-Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes

Xiang Wang et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

CuS-NiS2 nanomaterials for MRI guided phototherapy of gastric carcinoma via triggering mitochondria-mediated apoptosis and MLKL/CAPG-mediated necroptosis

Jian Chen et al.

NANOTOXICOLOGY (2020)

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Review Oncology

Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death

Zahra Asadzadeh et al.

CANCERS (2020)

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Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

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Article Chemistry, Multidisciplinary

Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

Kai Xiong et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Pharmacology & Pharmacy

The Mechanism of Ferroptosis and Applications in Tumor Treatment

Xinyue Lin et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Oncology

The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications

Sheng-Kai Hsu et al.

CANCERS (2020)

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Article Chemistry, Physical

Injectable Nonmagnetic Liquid Metal for Eddy-Thermal Ablation of Tumors under Alternating Magnetic Field

Nailin Yang et al.

SMALL METHODS (2020)

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Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Bimetallic Oxide FeWOXNanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment-Modulation and Enhanced Multimodal Cancer Therapy

Fei Gong et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Shuang Qing et al.

ADVANCED MATERIALS (2020)

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Review Engineering, Biomedical

Harnessing carbon monoxide-releasing platforms for cancer therapy

Yang Zhou et al.

BIOMATERIALS (2020)

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Article Cell Biology

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv et al.

CELL RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Eliciting Immunogenic Cell Death via a Unitized Nanoinducer

Zan Dai et al.

NANO LETTERS (2020)

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Review Chemistry, Multidisciplinary

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Fei Gong et al.

NANO TODAY (2020)

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Article Biochemistry & Molecular Biology

The tumor microenvironment

Nicole M. Anderson et al.

CURRENT BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancerin vivo

Wenmin Zhang et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Haozhe He et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

H2S-Scavenged and Activated Iron Oxide-Hydroxide Nanospindles for MRI-Guided Photothermal Therapy and Ferroptosis in Colon Cancer

Yangyang Li et al.

SMALL (2020)

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Article Multidisciplinary Sciences

Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy

Fei Gong et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

Shujuan Xu et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

Zhen Zhao et al.

CELL REPORTS (2020)

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Article Oncology

Carbon Nanodots for On Demand Chemophotothermal Therapy Combination to Elicit Necroptosis: Overcoming Apoptosis Resistance in Breast Cancer Cell Lines

Aldo Nicosia et al.

CANCERS (2020)

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Article Materials Science, Multidisciplinary

Magnesium-based micromotors for enhanced active and synergistic hydrogen chemotherapy

Kun Liu et al.

APPLIED MATERIALS TODAY (2020)

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Article Nanoscience & Nanotechnology

Biodegradable Fe-Doped Vanadium Disulfide Theranostic Nanosheets for Enhanced Sonodynamic/Chemodynamic Therapy

Huali Lei et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Tumor microenvironment responsive hollow mesoporous Co9S8@MnO2-ICG/DOX intelligent nanoplatform for synergistically enhanced tumor multimodal therapy

Junqing Huang et al.

BIOMATERIALS (2020)

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Article Engineering, Environmental

Cocktail polyprodrug nanoparticles concurrently release cisplatin and peroxynitrite-generating nitric oxide in cisplatin-resistant cancers

Chengyan Chu et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis

Parvathy R. Suma et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Oncology

Targeting immunogenic cell death in cancer

Asma Ahmed et al.

MOLECULAR ONCOLOGY (2020)

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Article Materials Science, Multidisciplinary

Fenton reaction-based nanomedicine in cancer chemodynamic and synergistic therapy

Xiangyu Meng et al.

APPLIED MATERIALS TODAY (2020)

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Review Chemistry, Multidisciplinary

Natural polyphenols in drug delivery systems: Current status and future challenges

Hui Wang et al.

GIANT (2020)

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Review Materials Science, Biomaterials

Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds

Joanna M. Sadowska et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Multidisciplinary

Oxygen-Deficient Bimetallic Oxide FeWOX Nanosheets as Peroxidase-Like Nanozyme for Sensing Cancer via Photoacoustic Imaging

Fei Gong et al.

SMALL (2020)

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Review Chemistry, Multidisciplinary

Tumor microenvironment triggered biodegradation of inorganic nanoparticles for enhanced tumor theranostics

Weitao Yang et al.

RSC ADVANCES (2020)

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Article Medicine, Research & Experimental

Ellagic acid-Fe@BSA nanoparticles for endogenous H2S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy

Qingqing Tian et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis

Hongxia Tang et al.

THERANOSTICS (2020)

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Review Chemistry, Multidisciplinary

Newly developed strategies for improving sonodynamic therapy

Xianwen Wang et al.

MATERIALS HORIZONS (2020)

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Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Oncology

Cause and effect of microenvironmental acidosis on bone metastases

Sofia Avnet et al.

CANCER AND METASTASIS REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors

Fangyuan Li et al.

NANO LETTERS (2019)

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Article Nanoscience & Nanotechnology

DNA-Templated Silver Nanocluster/Porphyrin/MnO2 Platform for Label-Free Intracellular Zn2+ Imaging and Fluorescence-/Magnetic Resonance Imaging-Guided Photodynamic Therapy

Yao Yao et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Engineering, Biomedical

Starvation-amplified CO generation for enhanced cancer therapy via an erythrocyte membrane-biomimetic gas nanofactory

Yuqian Wang et al.

ACTA BIOMATERIALIA (2019)

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Article Engineering, Biomedical

Acid-Responsive H2-Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy

Mingjian Fan et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

Jianrong Wu et al.

ADVANCED SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Deciphering the Atomic Patterns Leading to MnO2 Polymorphism

Yifei Yuan et al.

CHEM (2019)

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Article Engineering, Biomedical

Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy

Qianyun Tang et al.

BIOMATERIALS (2019)

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Article Multidisciplinary Sciences

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Wei Li et al.

NATURE COMMUNICATIONS (2019)

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Review Engineering, Biomedical

Micro/Nanomaterials-Augmented Hydrogen Therapy

Gaoxin Zhou et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Engineering, Biomedical

Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy

Xiaoqin Qian et al.

BIOMATERIALS (2019)

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Review Biochemistry & Molecular Biology

Elimination of Osteosarcoma by Necroptosis with Graphene Oxide-Associated Anti-HER2 Antibodies

Hongmei Xiao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy

Li Wang et al.

NANO LETTERS (2019)

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Article Biology

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

Thomas Scambler et al.

ELIFE (2019)

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Review Oncology

Hydrogen Gas in Cancer Treatment

Sai Li et al.

FRONTIERS IN ONCOLOGY (2019)

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Review Chemistry, Multidisciplinary

Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy

Yunjiao Zhang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for in Vivo Tracking of Protein Delivery in Cancer Therapy

Fenfen Zheng et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Tumor Microenvironment Responsive Shape Reversal Self-Targeting Virus-Inspired Nanodrug for Imaging-Guided Near-Infrared-II Photothermal Chemotherapy

Yang Li et al.

ACS NANO (2019)

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Review Materials Science, Biomaterials

Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review

Wenfeng Wei et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Nanoscience & Nanotechnology

Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies

Yun-Chieh Sung et al.

NATURE NANOTECHNOLOGY (2019)

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Review Pharmacology & Pharmacy

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Seyed Mohammadali Dadfar et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

Rong Cai et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects

Wenhua Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Cell Biology

Role of pyroptosis in cardiovascular disease

Zeng Zhaolin et al.

CELL PROLIFERATION (2019)

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Article Chemistry, Multidisciplinary

Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma

Hui Ding et al.

NANO LETTERS (2019)

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Article Chemistry, Physical

Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

Wenjun Zhu et al.

NANO RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Yichen Xu et al.

NATURE MEDICINE (2019)

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Review Immunology

Calcium signalling in T cells

Mohamed Trebak et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Enhancing tumor chemotherapy and overcoming drug resistance through autophagy-mediated intracellular dissolution of zinc oxide nanoparticles

Yi Hu et al.

NANOSCALE (2019)

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Article Materials Science, Biomaterials

Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

Zhu Kou et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Biochemistry & Molecular Biology

Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment

Jian Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

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Article Chemistry, Multidisciplinary

CuS-MnS2 nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis

Wancheng Chen et al.

NANOSCALE (2019)

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Article Engineering, Biomedical

pH/Ultrasound Dual-Responsive Gas Generator for Ultrasound Imaging-Guided Therapeutic Inertial Cavitation and Sonodynamic Therapy

Qianhua Feng et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Titania-Coated Gold Nano-Bipyramids for Blocking Autophagy Flux and Sensitizing Cancer Cells to Proteasome Inhibitor-Induced Death

Hong-Ye Wan et al.

ADVANCED SCIENCE (2018)

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Article Nanoscience & Nanotechnology

In Vivo Targeted, Responsive, and Synergistic Cancer Nanotheranostics by Magnetic Resonance Imaging-Guided Synergistic High-Intensity Focused Ultrasound Ablation and Chemotherapy

Hailin Tang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Oncology

Cancer stem cell in breast cancer therapeutic resistance

Xupeng Bai et al.

CANCER TREATMENT REVIEWS (2018)

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Review Chemistry, Multidisciplinary

Omnipotent phosphorene: a next-generation, two-dimensional nanoplatform for multidisciplinary biomedical applications

Meng Qiu et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Article Biophysics

Human nitric oxide biomarker as potential NO donor in conjunction with superparamagnetic iron oxide @ gold core shell nanoparticles for cancer therapeutics

Nimisha Singh et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Immunology

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Chenguang Wang et al.

IMMUNITY (2018)

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Editorial Material Oncology

IMMUNOTHERAPY Cancer immunotherapy and the value of cure

Joseph C. Del Paggio

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Multidisciplinary Sciences

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Mingjian Du et al.

SCIENCE (2018)

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Review Medicine, Research & Experimental

Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics

Wensheng Xie et al.

THERANOSTICS (2018)

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Article Materials Science, Biomaterials

An intelligent and biocompatible photosensitizer conjugated silicon quantum dots-MnO2 nanosystem for fluorescence imaging-guided efficient photodynamic therapy

Rong-gui Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Chemistry, Multidisciplinary

Recent Development of Inorganic Nanoparticles for Biomedical Imaging

Dokyoon Kim et al.

ACS CENTRAL SCIENCE (2018)

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Article Chemistry, Multidisciplinary

Bimetallic Oxide MnMoOx Nanorods for in Vivo Photoacoustic Imaging of GSH and Tumor-Specific Photothermal Therapy

Fei Gong et al.

NANO LETTERS (2018)

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Article Chemistry, Multidisciplinary

Nanocellulose templated growth of ultra-small bismuth nanoparticles for enhanced radiation therapy

Li Jiao et al.

NANOSCALE (2018)

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Article Chemistry, Multidisciplinary

A theranostic nanoplatform: magneto-gold@fluorescence polymer nanoparticles for tumor targeting T1&T2-MRI/CT/NIR fluorescence imaging and induction of genuine autophagy mediated chemotherapy

Guannan Wang et al.

NANOSCALE (2018)

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Article Chemistry, Multidisciplinary

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

Shuaifei Wang et al.

ACS NANO (2018)

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Article Cell Biology

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Bo Zhou et al.

CELL RESEARCH (2018)

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Article Chemistry, Analytical

Biodegradable nanoprobe based on MnO2 nanoflowers and graphene quantum dots for near infrared fluorescence imaging of glutathione in living cells

Zhi-Ling Song et al.

MICROCHIMICA ACTA (2018)

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Gold nanoparticles impair autophagy flux through shape-dependent endocytosis and lysosomal dysfunction

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JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Diiron Hexacarbonyl Complex Induces Site-Specific Release of Carbon Monoxide in Cancer Cells Triggered by Endogenous Glutathione

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ACS OMEGA (2018)

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Intratumoral high-payload delivery and acid-responsive release of H-2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine

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APPLIED MATERIALS TODAY (2018)

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Bioactive inorganic/organic nanocomposites for wound healing

Xiaocheng Wang et al.

APPLIED MATERIALS TODAY (2018)

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Developing a pH-sensitive Al(OH)(3) layer-mediated UCNP@Al(OH)(3)/Au nanohybrid for photothermal therapy and fluorescence imaging in vivo

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JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Chemistry, Multidisciplinary

Smart Microbubble Eluting Theranostic Stent for Noninvasive Ultrasound Imaging and Prevention of Restenosis

Do Hee Keum et al.

SMALL (2017)

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In Vivo Long-Term Biodistribution, Excretion, and Toxicology of PEGylated Transition-Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets

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ADVANCED SCIENCE (2017)

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Article Biochemistry & Molecular Biology

Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells

Wen Sun et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Alkynyl gold(I) complex triggers necroptosis via ROS generation in colorectal carcinoma cells

Ines Marmol et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2017)

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Review Materials Science, Biomaterials

Advanced review of graphene-based nanomaterials in drug delivery systems: Synthesis, modification, toxicity and application

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MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Hirotaka Ejima et al.

NANO TODAY (2017)

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Editorial Material Biotechnology & Applied Microbiology

Biodegradable inorganic nanoparticles: an opportunity for improved cancer therapy?

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NANOMEDICINE (2017)

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In vivo aggregation-induced transition between T1 and T2 relaxations of magnetic ultra-small iron oxide nanoparticles in tumor microenvironment

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NANOSCALE (2017)

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Microenvironmental autophagy promotes tumour growth

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NATURE (2017)

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

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NATURE (2017)

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LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis

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NEUROCHEMICAL RESEARCH (2017)

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Review Cell Biology

Aspects of Carbon Monoxide in Form of CO-Releasing Molecules Used in Cancer Treatment: More Light on the Way

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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A Smart Responsive Dual Aptamers-Targeted Bubble-Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging

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SMALL (2017)

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Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

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TRENDS IN BIOCHEMICAL SCIENCES (2017)

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Tumor microenvironment-triggered fabrication of gold nanomachines for tumor-specific photoacoustic imaging and photothermal therapy

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CHEMICAL SCIENCE (2017)

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In situ formation of pH-responsive Prussian blue for photoacoustic imaging and photothermal therapy of cancer

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RSC ADVANCES (2017)

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Review Materials Science, Biomaterials

Activatable probes for diagnosis and biomarker detection by MRI

Monica Carril

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation

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JOURNAL OF NANOBIOTECHNOLOGY (2017)

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Editorial Material Chemistry, Analytical

Biomedical Applications of Nanotechnology and Nanomaterials

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MICROMACHINES (2017)

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Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells

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SCIENCE BULLETIN (2017)

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Cancer nanomedicine: progress, challenges and opportunities

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NATURE REVIEWS CANCER (2017)

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Recent advances in activatable fluorescence imaging probes for tumor imaging

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DRUG DISCOVERY TODAY (2017)

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Review Engineering, Biomedical

Nanomaterials for cancer immunotherapy

Wantong Song et al.

BIOMATERIALS (2017)

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Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

H2S-Activable MOF Nanoparticle Photosensitizer for Effective Photodynamic Therapy against Cancer with Controllable Singlet-Oxygen Release

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

Induction of Necroptosis in Cancer Stem Cells using a Nickel(II)Dithiocarbamate Phenanthroline Complex

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CHEMISTRY-A EUROPEAN JOURNAL (2017)

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A Biohybrid Lurker-to-Attacker Strategy To Solve Inherent Dilemma of Positively Charged Delivery Nanoparticles

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CHEMISTRY OF MATERIALS (2017)

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CA-A CANCER JOURNAL FOR CLINICIANS (2016)

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CELL DEATH AND DIFFERENTIATION (2016)

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Ferroptosis is an autophagic cell death process

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CELL RESEARCH (2016)

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Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy

Teng Liu et al.

NANO RESEARCH (2016)

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Corrosion-Activated Chemotherapeutic Function of Nanoparticulate Platinum as a Cisplatin Resistance-Overcoming Prodrug with Limited Autophagy Induction

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SMALL (2016)

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Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Jundong Shao et al.

NATURE COMMUNICATIONS (2016)

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Article Engineering, Biomedical

pH-Responsive Fe(III)-Gallic Acid Nanoparticles for In Vivo Photoacoustic-Imaging-Guided Photothermal Therapy

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ADVANCED HEALTHCARE MATERIALS (2016)

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Article Chemistry, Multidisciplinary

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

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ACS CENTRAL SCIENCE (2016)

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Article Chemistry, Multidisciplinary

Iron Oxide Decorated MoS2 Nanosheets with Double PEGylation for Chelator-Free Radio labeling and Multimodal Imaging Guided Photothermal Therapy

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ACS NANO (2015)

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Article Chemistry, Multidisciplinary

Bottom-Up Synthesis of Metal-Ion-Doped WS2 Nanoflakes for Cancer Theranostics

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ACS NANO (2015)

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Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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Cobalt Chloride Induces Necroptosis in Human Colon Cancer HT-29 Cells

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Asian Pacific Journal of Cancer Prevention (2015)

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Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor

Shige Wang et al.

BIOMATERIALS (2015)

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Article Chemistry, Physical

Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects

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CHEMISTRY OF MATERIALS (2015)

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Necroptosis-Inducing Rhenium(V) Oxo Complexes

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Ferroptosis as a p53-mediated activity during tumour suppression

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Review Chemistry, Multidisciplinary

Review: physico-chemical modification as a versatile strategy for the biocompatibility enhancement of biomaterials

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RSC ADVANCES (2015)

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Nanomaterials for Engineering Stem Cell Responses

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Acute exposure to ZnO nanoparticles induces autophagic immune cell death

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NANOTOXICOLOGY (2015)

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Review Chemistry, Multidisciplinary

Preparation and Applications of Mechanically Exfoliated Single-Layer and Multi layer MoS2 and WSe2 Nanosheets

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ACCOUNTS OF CHEMICAL RESEARCH (2014)

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Engineering Multifunctional Capsules through the Assembly of Metal-Phenolic Networks

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Ultrathin WS2 Nanoflakes as a High-Performance Electrocatalyst for the Hydrogen Evolution Reaction

Liang Cheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

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CELL (2014)

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Review Chemistry, Multidisciplinary

Functional Nanomaterials for Phototherapies of Cancer

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CHEMICAL REVIEWS (2014)

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Arsenic Trioxide and Other Arsenical Compounds Inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 Inflammasomes

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JOURNAL OF IMMUNOLOGY (2014)

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Pyrogallol 2-Aminoethane: A Plant Flavonoid-Inspired Molecule for Material-Independent Surface Chemistry

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ADVANCED MATERIALS INTERFACES (2014)

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Article Chemistry, Multidisciplinary

MnO Nanocrystals: A Platform for Integration of MRI and Genuine Autophagy Induction for Chemotherapy

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ADVANCED FUNCTIONAL MATERIALS (2013)

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Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

Barbara Wegiel et al.

CANCER RESEARCH (2013)

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Raul Munoz-Planillo et al.

IMMUNITY (2013)

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Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

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NATURE (2013)

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Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

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SCIENCE (2013)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

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NATURE COMMUNICATIONS (2012)

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Hallmarks of Cancer: The Next Generation

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Two-Dimensional Nanosheets Produced by Liquid Exfoliation of Layered Materials

Jonathan N. Coleman et al.

SCIENCE (2011)

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Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21

Wen-Jie Cai et al.

CELL BIOLOGY INTERNATIONAL (2010)

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Boron nitride substrates for high-quality graphene electronics

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Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal

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AUTOPHAGY (2009)

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Tumor microenvironment and angiogenesis

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FRONTIERS IN BIOSCIENCE (2008)

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Review Cell Biology

The tumor microenvironment and its contribution to tumor evolution toward metastasis

Girieca Lorusso et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2008)

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Review Biotechnology & Applied Microbiology

Hydrogen sulphide and its therapeutic potential

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2007)

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Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress

Kei-Ichi Fukuda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Hydrothermal synthesis and characterization of single-crystalline Fe3O4 nanowires with high aspect ratio and uniformity

Kai He et al.

MATERIALS LETTERS (2007)

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Sulfide, the first inorganic substrate for human cells

Marc Goubern et al.

FASEB JOURNAL (2007)

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Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization

Maho Nagae et al.

JOURNAL OF BONE AND MINERAL METABOLISM (2007)

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Review Oncology

The role of nitric oxide in tumour progression

Dai Fukumura et al.

NATURE REVIEWS CANCER (2006)

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Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells

Y Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Crystallography

A soft-template-assisted hydrothermal approach to single-crystal Fe3O4 nanorods

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JOURNAL OF CRYSTAL GROWTH (2005)

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Article Chemistry, Multidisciplinary

Single crystalline magnetite nanotubes

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

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Ultra-large-scale syntheses of monodisperse nanocrystals

J Park et al.

NATURE MATERIALS (2004)

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Electric field effect in atomically thin carbon films

KS Novoselov et al.

SCIENCE (2004)

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Review Cell Biology

The role of nitric oxide in cancer

WM Xu et al.

CELL RESEARCH (2002)

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Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice

K Kinjo et al.

LEUKEMIA (2000)

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