Construction and Application of DNAzyme-based Nanodevices

The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.

Automated summary

The development of stimuli-responsive nanodevices with high efficiency and specificity is crucial in biosensing and drug delivery. DNAzymes, a class of DNA molecules with specific catalytic activity, have drawn much attention due to their unique properties and easy design. This review provides an introduction to DNAzyme classification and properties, and systematically summarizes the construction of various DNAzyme-based nanodevices such as motors, amplifiers, and logic gates. The application of DNAzyme-based nanodevices in sensing and therapeutics is also discussed, along with current limitations and future directions.