期刊
CHEMICAL ENGINEERING JOURNAL
卷 448, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.137630
关键词
Electrochemiluminescence; Surface plasmon coupling; Polarization-resolved; Patterned structure
资金
- National Natural Science Foundation of China [22174051]
- science research project in the Education Department of Jilin Province, China [JJKH20211050KJ]
A polarization-resolved surface plasmon coupling electrochemiluminescence (ECL) strategy based on orientational Au nanobipyramids (Au NBPs) patterned structures was developed. By controlling the patterned structures of Au NBPs, the polarized emission of SnS2 quantum dots was modulated, enabling the analysis of miRNA-21 and miRNA-205 expression levels in tumor tissues of triple negative breast cancer patients.
Here, we developed a polarization-resolved surface plasmon coupling electrochemiluminescence (ECL) strategy based on orientational Au nanobipyramids (Au NBPs) patterned structures. As the surface plasmonic materials, the Au NBPs with large localized electromagnetic field enhancement were used to construct the different patterned structures through the droplet evaporation induced assembly. The distinct morphology of the horizontal and vertical Au NBPs patterned structures provided the different plasmonic properties reflecting on resonance peak positions and polarized absorbance. As a result, the variations of the polarized ECL emission of SnS2 QDs have been regulated by the Au NBPs patterned structures via the surface plasmon coupling progress. Because of the superior polarization-resolved ECL performances, the sensing system was used to analyze the miRNA-21 and miRNA-205 expression level in tumor tissues of triple negative breast cancer patients. The satisfactory results indicated this polarization-resolved sensing strategy possessed great potential for clinical analysis.
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