4.7 Article

A ratiometric fluorescent biosensing strategy based on a composite nanoplatform and dual signal amplification for exosomal miRNA detection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Analytical

Enzyme-free and copper-free strategy based on cyclic click chemical-triggered hairpin stacking circuit for accurate detection of circulating microRNAs

Shuang Zhao et al.

Summary: In this study, an enzyme-free fluorescence resonance energy transfer assay (3C-TASK) was developed for the detection of circulating microRNAs (miRNAs). The 3C-TASK utilized click chemical ligation reactions and hairpin stacking circuits to achieve sensitive and specific detection of miRNA. This method offers a new perspective for the broader application of enzyme-free chemical reactions and DNA circuits in biosensing.

ANALYTICA CHIMICA ACTA (2022)

Article Chemistry, Analytical

Photoelectrochemical Detection of Exosomal miRNAs by Combining Target-Programmed Controllable Signal Quenching Engineering

Yanhu Wang et al.

Summary: A sensitive photoelectrochemical (PEC) biosensing platform was demonstrated for exosomal miRNA assay using lambda-exonuclease for amplification strategy, while a target exosomal miRNA-activatable release nanocarrier was fabricated to enable signal control. This study provides a feasible approach for the efficient diagnosis and prognosis prediction of diseases based on the detection of exosomal miRNAs-21.

ANALYTICAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Reexamining assumptions about miRNA-guided gene silencing

Audrius Kilikevicius et al.

Summary: MicroRNAs (miRNAs) have the potential to regulate the expression of any RNA, but our understanding of their molecular mechanism is still limited. Insufficient focus on the mechanism of miRNAs and lack of evidence linking specific miRNA expression to biological phenotypes have hindered our accurate understanding of miRNA function.

NUCLEIC ACIDS RESEARCH (2022)

Article Chemistry, Analytical

DNA nanolantern-mediated catalytic hairpin assembly nanoamplifiers for simultaneous detection of multiple microRNAs

Ya-Xin Wang et al.

Summary: The study developed a highly integrated DNA nanoamplifier by anchoring hairpin probes on the surface of DNA nanolantern, enabling high sensitivity detection of miRNAs. The nanoamplifier showed enhanced signal amplification capability, accelerated reaction kinetics, and enabled miRNA imaging and analysis in living cells and mice.

TALANTA (2022)

Article Chemistry, Analytical

Isothermal and enzyme-free MicroRNA assay based on catalytic hairpin assembly and rare earth element labeled probes

Jiawei Shen et al.

Summary: This study proposes an isothermal and enzyme-free miRNA assay based on CHA amplification and ICP-MS detection. By utilizing hybridization reaction and CHA cycles, high sensitivity and specificity analysis of miRNA-141 were achieved. The method also demonstrated multiple detecting capability and the potential of becoming a high-throughput method.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Article Chemistry, Analytical

Rapid and enzyme-free signal amplification for fluorescent detection of microRNA via localized catalytic hairpin assembly on gold nanoparticles

Qiang Liu et al.

Summary: In this study, an enzyme-free signal amplification method for miRNA detection was developed using target-triggered catalytic hairpin assembly (CHA). The method showed high sensitivity and fast detection speed, with good recoveries in serum samples.

TALANTA (2022)

Article Chemistry, Analytical

Fluorescent and electrochemical bimodal bioplatform for femtomolar detection of microRNAs in blood sera

Riham Zayani et al.

Summary: The study introduces a novel method for sensitive detection of miRNAs levels using a dual signal readout system involving competitive hybridization of miR-21 target and its biotinylated analog. The bioplatform demonstrates low detection limits, wide linear calibration range, excellent selectivity towards non-complementary miRs, and acceptable distinction with single nucleotide mismatched sequences. Furthermore, the method was successfully used to determine miR-21 expression levels in blood sera from breast cancer patients.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Article Spectroscopy

Fluorescence detections of hydrogen peroxide and glucose with polyethyleneimine-capped silver nanoclusters

Ting Zhou et al.

Summary: Detection of hydrogen peroxide and glucose was enhanced by utilizing the oxidative property of hydrogen peroxide. Fluorescence from photoluminescent silver nanoclusters could be quenched by reduced glutathione, offering a sensitive detection method. The study demonstrated successful application of this method for glucose measurement in human serum samples.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

Article Chemistry, Physical

Effects of silver nanoclusters on the spectral properties for fluorescein isothiocyanate with restrained photobleaching

Pengyuan Shan et al.

Summary: This study investigates the energy transfer process between silver nanoclusters (Ag NCs) with different emission wavelengths and fluorescein isothiocyanate (FITC). It shows that FITC can act as an electron donor or acceptor, determining the direction of electron transfer between FITC and Ag NCs with different emissions. Additionally, the interaction with Ag NCs effectively inhibits the photo bleaching of FITC, which has significant implications for the application of FITC.

APPLIED SURFACE SCIENCE (2021)

Review Engineering, Biomedical

Progress in the research of nanomaterial-based exosome bioanalysis and exosome-based nanomaterials tumor therapy

Zhiwei Sun et al.

Summary: Exosomes and nanomaterials have shown great potential in overcoming challenges in bioanalysis. The research progress in utilizing nanomaterials for exosome analysis has advanced significantly, offering promising clinical applications. The future development of this field holds great potential for innovative methods in biomedical research.

BIOMATERIALS (2021)

Article Chemistry, Applied

Graphite-like carbon nitride-laden gold nanoparticles as signal amplification label for highly sensitive lateral flow immunoassay of 17β-estradiol

Xiaolin Yao et al.

Summary: A LFIA method utilizing graphite-like carbon nitride-laden gold nanoparticles was developed to enhance sensitivity for 17 beta-estradiol in foods, achieving a three-fold improvement in analytical performance compared to conventional gold nanoparticles-based LFIA. This method was successfully applied to detect estrogen in contaminated food samples, indicating great potential for its application in food products.

FOOD CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

DNA-Templated Fluorescent Silver Nanoclusters Inhibit Bacterial Growth While Being Non-Toxic to Mammalian Cells

Lewis Rolband et al.

Summary: This study combines atomically precise metal nanoclusters with nucleic acid nanotechnology to create DNA-templated silver nanoclusters with reproducible fluorescent properties and antibacterial activity. Additionally, the use of cytosine-rich single-stranded DNA oligonucleotides improves stability, modulates antibacterial properties, and enhances the quality of observed fluorescent signals of the silver nanoclusters. The research characterizes the sequence-specific fluorescence and composition of four representative DNA-AgNCs, compares their antibacterial effectiveness at different pH levels, and evaluates cytotoxicity to various mammalian cell lines.

MOLECULES (2021)

Article Chemistry, Analytical

An amine-functionalized metal-organic framework and triple-helix molecular beacons as a sensing platform for miRNA ratiometric detection

Yunpeng Han et al.

Summary: In this study, a metal-organic framework with intrinsic fluorescence and fluorescence quenching ability was designed for high-performance miRNA detection, showing good sensitivity and selectivity for detecting miRNA-203. The ratiometric fluorescent platform can eliminate interference caused by the sensing environment, providing accurate detection results in laboratory and biological samples.

TALANTA (2021)

Review Biochemistry & Molecular Biology

Challenges in Using Circulating Micro-RNAs as Biomarkers for Cardiovascular Diseases

Kyriacos Felekkis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Review Chemistry, Analytical

Recent advances in the bioanalytical and biomedical applications of DNA-templated silver nanoclusters

Jiaqi Xu et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2020)

Article Medicine, Research & Experimental

Discovering Cancer-Related miRNAs from miRNA-Target Interactions by Support Vector Machines

Cong Pian et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Immunology

Clinical significance of miRNAs in autoimmunity

Lian Zhang et al.

JOURNAL OF AUTOIMMUNITY (2020)

Review Biochemistry & Molecular Biology

The role of synaptic microRNAs in Alzheimer's disease

Subodh Kumar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Article Nanoscience & Nanotechnology

Self-Tracking Multifunctional Nanotheranostics for Sensitive miRNA Imaging Guided Photodynamic Therapy

Xiangnan Wang et al.

ACS APPLIED BIO MATERIALS (2020)

Article Chemistry, Analytical

Ratiometric fluorescent biosensor for microRNAs imaging in living cells

Dongsheng Zhou et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

Review Cell Biology

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

Marcelo A. Mori et al.

CELL METABOLISM (2019)

Review Cell Biology

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Kioomars Saliminejad et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Giuseppina Emanuela Grieco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Post-transcriptional control of miRNA biogenesis

Gracjan Michlewski et al.

Article Multidisciplinary Sciences

Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor

Tianyu Xue et al.

NATURE COMMUNICATIONS (2019)

Article Materials Science, Biomaterials

g-C3N4 nanosheet-based ratiometric fluorescent probes for the amplification and imaging of miRNA in living cells

Yiting Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Article Chemistry, Physical

Poly(N-vinylimidazole) assisted formation of bright far-red/near infrared gold nanocluster aggregates

Tong-Xian Zhang et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2018)

Article Nanoscience & Nanotechnology

One-Step Synthesis of DNA Templated Water-Soluble Au-Ag Bimetallic Nanoclusters for Ratiometric Fluorescence Detection of DNA

Taotao Li et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

Review Gastroenterology & Hepatology

Can technology increase adenoma detection rate?

Wee Sing Ngu et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2018)

Article Nanoscience & Nanotechnology

In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe

Ling-Yan Zhai et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Biochemistry & Molecular Biology

A metal-organic framework based PCR-free biosensor for the detection of gastric cancer associated microRNAs

Gui-Hua Qiu et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2017)