DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity

We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.

Automated summary

We have developed a class of amphiphilic drug complexes by programming hydrophobic drug patterns on DNA frameworks. We have investigated the impact of these drug patterns on cellular uptake efficiency and drug potency, and have achieved enhanced cytotoxicity against tumor cells through the use of an asymmetric drug pattern.