An anti-poisoning nanosensor for in situ monitoring of intracellular endogenous hydrogen sulfide

Intracellular H2S plays an important regulatory role in cell metabolism. The limited sensing materials and severe sensor passivation hinder its quantification. We functionalized conductive nanowires with MoS2 and quercetin in a large-scale manner, developed single nanowire sensors with excellent electrocatalytic and anti-poisoning performance, and achieved the accurate quantification of H2S within single cells.

Automated summary

Intracellular H2S is crucial for regulating cell metabolism, but its quantification is hindered by the limited sensing materials and sensor passivation. In this study, we functionalized conductive nanowires with MoS2 and quercetin to develop single nanowire sensors with excellent electrocatalytic and anti-poisoning performance, enabling accurate quantification of H2S within single cells.