Water-soluble NHC Pd/Ni bimetallic nanoparticles for H/D exchange in aromatic amino-acids

Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an enantiospecific fashion without reducing the aromatic ring of phenylalanine and tyrosine thanks to a synergetic Pd-Ni effect.

Automated summary

In this study, a new NHC-stabilized water-soluble Pd/Ni system is presented, which can perform H/D exchange reactions in an enantiospecific manner without reducing the aromatic ring of phenylalanine and tyrosine due to a synergetic Pd-Ni effect.