Non-porous silica support covalent organic frameworks as stationary phases for liquid chromatography

A new strategy using non-porous silica (NPS) spheres as the support and covalent organic frameworks (COFs) as the porous functional shell for liquid chromatography was developed to ensure the independent effect of the COFs on the separation. As a proof of concept, NPS@TPB-DMTP was prepared for liquid chromatographic analysis using 1,3,5-tris(4-aminophenyl)benzene (TPB) and 2,5-dimethoxy-1,4-benzenedicarboxaldehyde (DMTP) as monomers by in situ polymerisation on the surface of NPS. It is a new way of developing COF-based stationary phases, which will be helpful in understanding what effect the COFs will have on separation.

Automated summary

A new strategy using non-porous silica (NPS) spheres as support and covalent organic frameworks (COFs) as porous functional shell was developed for liquid chromatography, ensuring the independent effect of COFs on separation. NPS@TPB-DMTP was prepared as proof of concept using 1,3,5-tris(4-aminophenyl)benzene (TPB) and 2,5-dimethoxy-1,4-benzenedicarboxaldehyde (DMTP) as monomers by in situ polymerization on the surface of NPS. This new approach of developing COF-based stationary phases will aid in understanding the impact of COFs on separation.