Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

Glutathione-responsive nanogels (CDNPs) crosslinked via crosslinker DBHD with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib were fabricated. The CDNPs can effectively induce tumor cell pyroptosis to activate robust antitumor immunity. Additionally, CDNPs combined with alpha PD-1 antibody greatly inhibited tumor growth in a melanoma mouse model with a prolonged survival time.

Automated summary

Glutathione-responsive nanogels (CDNPs) crosslinked with crosslinker DBHD incorporating BRAF inhibitor dabrafenib and COX2 inhibitor celecoxib were synthesized. The CDNPs can efficiently induce tumor cell pyroptosis and activate strong antitumor immunity. Furthermore, CDNPs combined with alpha PD-1 antibody significantly suppressed tumor growth and prolonged survival in a melanoma mouse model.