Selectfluor®-enabled photochemical selective C(sp3)-H(sulfonyl)amidation

Transition metal- and photosensitizer-free C(sp(3))-H (sulfonyl)amidation reactions have been realized by employing Selectfluor (R) as a versatile reagent, functioning as a photoactive component, a HAT precursor and an oxidant. Various toluene derivatives, cycloalkanes, natural products and bioactive molecules can be converted into N-containing products under mild conditions in good yield and with high chemo- and site-selectivity.

Automated summary

Transition metal- and photosensitizer-free C(sp(3))-H (sulfonyl)amidation reactions have been successfully achieved using SelectFluor (R) as a versatile reagent, showing mild reaction conditions and high yields and selectivity for the formation of N-containing products from various compounds.