Global diversity in individualized cortical network topography

Individualized cortical network topography (ICNT) varies between people and exhibits great variability in the association networks in the human brain. However, these findings were mainly discovered in Western populations. It remains unclear whether and how ICNT is shaped by the non-Western populations. Here, we leveraged a multisession hierarchical Bayesian model to define individualized functional networks in White American and Han Chinese populations with data from both US and Chinese Human Connectome Projects. We found that both the size and spatial topography of individualized functional networks differed between White American and Han Chinese groups, especially in the heteromodal association cortex (including the ventral attention, control, language, dorsal attention, and default mode networks). Employing a support vector machine, we then demonstrated that ethnicity-related ICNT diversity can be used to identify an individual's ethnicity with high accuracy (74%, p(perm) < 0.0001), with heteromodal networks contributing most to the classification. This finding was further validated through mass-univariate analyses with generalized additive models. Moreover, we reveal that the spatial heterogeneity of ethnic diversity in ICNT correlated with fundamental properties of cortical organization, including evolutionary cortical expansion, brain myelination, and cerebral blood flow. Altogether, this case study highlights a need for more globally diverse and publicly available neuroimaging datasets.

Automated summary

Individualized cortical network topography (ICNT) varies between people, but most findings are based on Western populations. This study investigates ICNT differences between White American and Han Chinese populations and demonstrates that ICNT diversity can accurately classify an individual's ethnicity, with heteromodal networks playing a major role. The study also reveals correlations between spatial heterogeneity in ICNT diversity and fundamental cortical organization properties. This case study emphasizes the need for globally diverse and publicly available neuroimaging datasets.