期刊
CELLULOSE
卷 30, 期 5, 页码 3073-3082出版社
SPRINGER
DOI: 10.1007/s10570-023-05070-6
关键词
Carboxymethyl cellulose; Diffusion model; Sustained-release
In this study, a sustained-release gel for chlorine dioxide (ClO2) gas was developed using degradable materials such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and beta-cyclodextrin (beta CD) through a simple and benign crosslinking strategy. The gel showed sustained-release property within a wide temperature range and released ClO2 gas effectively for more than 30 days. A new diffusion model based on the Korsmeyer-Peppas model was proposed and achieved an excellent fit. This sustained-release gel provides guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained-release model of skeleton-soluble hydrogels.
Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO2) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO2 as a model drug, and a sustained-ClO2-gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and beta-cyclodextrin (beta CD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4-35 ? and released ClO2 gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer-Peppas model, and an excellent fit was obtained. This sustained-ClO2-gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels.
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