DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer

Review Urology & Nephrology

International Bladder Cancer Group Consensus Statement on Clinical Trial Design for Patients with Bacillus Calmette-Guerin-exposed High-risk Non-muscle-invasive Bladder Cancer

Mathieu Roumiguie et al.

Summary: The study aims to develop optimal trial design for patients with BCG-exposed NMIBC, emphasizing the need to define the disease state clearly and providing specific recommendations and guidance.

EUROPEAN UROLOGY (2022)

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Review Biochemistry & Molecular Biology

Medication effects on developmental sterol biosynthesis

Zeljka Korade et al.

Summary: Cholesterol is crucial for normal brain function and development, with disruptions in sterol biosynthesis potentially leading to intellectual and developmental disabilities. Many commonly prescribed medications interfere with sterol biosynthesis, which when used during pregnancy can have detrimental effects on the developing brain of the offspring. Inhibiting the last enzyme in biosynthesis pathway can result in accumulation of toxic oxysterols, posing risks to both mice and humans carrying certain genotype mutations.

MOLECULAR PSYCHIATRY (2022)

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Article Chemistry, Multidisciplinary

Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates

Keke Ding et al.

Summary: This study developed a photoenhanced cancer chemotherapy strategy using near-infrared fluorescence imaging, photodynamic therapy, and photothermal therapy to enhance the sensitivity of bladder cancer to cisplatin chemotherapy with minimal side effects.

ACS NANO (2022)

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Article Nutrition & Dietetics

Tea consumption and risk of bladder cancer in the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) Study: Pooled analysis of 12 international cohort studies

Abdulmohsen H. Al-Zalabani et al.

Summary: Higher consumption of tea is associated with a reduced risk of bladder cancer, especially among men and smokers. Further studies are needed to clarify the mechanisms of the protective effect of tea and its interaction with smoking and sex.

CLINICAL NUTRITION (2022)

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Article Endocrinology & Metabolism

The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells

Liqian Ma et al.

Summary: Dysregulation of cholesterol homeostasis is associated with various diseases. Liver X receptors (LXRs), as major regulators of cholesterol homeostasis, can be selectively modulated by different ligands, influencing multiple biological systems. This study provides evidence of LXR selective modulation through gene expression analysis, laying the foundation for developing precision pharmacology LXR ligands.

ENDOCRINOLOGY (2022)

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Article Food Science & Technology

In vitro and in vivo anti-tumor efficacy of krill oil against bladder cancer: Involvement of tumor-associated angiogenic vasculature

Hoon Kim et al.

Summary: Krill oil has shown significant effects on inhibiting bladder tumor cell proliferation, migration, and invasion. It can regulate multiple signaling pathways and cell cycle progression. Moreover, it can inhibit tumor-associated angiogenesis, leading to suppression of tumor growth and metastasis.

FOOD RESEARCH INTERNATIONAL (2022)

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Article Public, Environmental & Occupational Health

Opium use and risk of bladder cancer: a multi-centre case-referent study in Iran

Maryam Hadji et al.

Summary: A study conducted in Iran found that regular opium use is associated with an increased risk of bladder cancer, but the risk decreases with time since cessation of opium use. Additionally, simultaneous use of opium and tobacco can further increase the risk of developing bladder cancer.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2022)

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Article Oncology

TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

Ming Chi et al.

Summary: This study identified BLCA-related genes and found that TEAD4 plays an important role in EMT dysregulation. Overexpression of TEAD4 is associated with poor prognosis, invasion, and metastasis of BLCA, mediated through the regulation of the PI3K/AKT pathway. Therefore, TEAD4 is not only an effective biomarker for predicting prognosis but also a potential target for the treatment of metastatic BLCA.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of the Hybrid Tracer Indocyanine Green-99mTc-Nanocolloid for Sentinel Node Biopsy in Bladder Cancer-A Prospective Pilot Study

Daphne D. D. Rietbergen et al.

Summary: Sentinel node biopsy in bladder cancer using the hybrid tracer ICG-Tc-99m-nanocolloid is feasible. Preoperative imaging is predictive for the ability to perform SN biopsy in 83% of the patients who displayed an SN. In patients with successful preoperative SN mapping, the intraoperative SN guidance and detection were effective.

CLINICAL NUCLEAR MEDICINE (2022)

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Review Oncology

Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer

Motahareh Mortazavi et al.

Summary: This study highlights the role of PI3K/AKT/mTOR pathway in pancreatic ductal adenocarcinoma, but clinical studies have not been promising. Patient stratification is identified as a crucial factor.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Article Environmental Sciences

Genetic variants of antioxidant enzymes and environmental exposures as molecular biomarkers associated with the risk and aggressiveness of bladder cancer

D. Martin-Way et al.

Summary: Bladder cancer is one of the most common tumors globally, and this study aims to identify molecular markers and risk factors associated with it. The study found several genes associated with bladder cancer risk, as well as environmental exposures and dietary chemicals that contribute to the disease. The study also identified specific miRNA expression patterns that are elevated in bladder cancer cases. These findings suggest the potential use of non-invasive biomarkers and personalized medicine for bladder cancer management.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Urology & Nephrology

Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer

Raquel Carrasco et al.

Summary: We identified the TERT c.-124C > T mutation as a potential biomarker of aggressivity in MIBC patients after RC, and found that CTC enumeration is an independent prognostic biomarker for tumor progression and cancer specific survival. CTC enumeration can detect tumor progression earlier than imaging techniques.

WORLD JOURNAL OF UROLOGY (2022)

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Article Nutrition & Dietetics

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway

Xiao-Dong Pei et al.

Summary: 6-Shogaol, an active compound from ginger, inhibits cell proliferation and migration in cervical cancer cells, induces cell cycle arrest at G2/M phase, and triggers apoptosis through the mitochondrial pathway by downregulating expression levels of related proteins.

EUROPEAN JOURNAL OF NUTRITION (2021)

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Article Biochemistry & Molecular Biology

KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer

Yaoyi Xiong et al.

Summary: This study identified an oncogene KNSTRN that promotes tumorigenesis and gemcitabine resistance by activating AKT phosphorylation. KNSTRN interacts with PTEN and AKT at the cell membrane, facilitating AKT movement to PIP3 for activation. The findings suggest that KNSTRN may serve as a potential therapeutic target for bladder cancer.

ONCOGENE (2021)

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Article Biochemistry & Molecular Biology

lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway

Guoqing Yang et al.

Summary: The study revealed that the high expression of ADAMTS9-AS1 in bladder cancer promotes cell proliferation, migration, and invasion while reducing apoptosis and autophagy. It was also observed that ADAMTS9-AS1 may regulate these processes through the PI3K/AKT/mTOR signaling pathway. Targeting ADAMTS9-AS1 could be a potential therapeutic approach for treating bladder cancer.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

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Article Cell Biology

E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability

Huimin Xu et al.

Summary: RNF126 is highly expressed in various cancers and acts as an oncogene in bladder cancer by promoting cell proliferation and metastasis through the EGFR/PI3K/AKT signaling pathway. It directly interacts with and regulates the stability of PTEN, an inhibitor of the PI3K/AKT pathway, through poly-ubiquitination. Knockdown of PTEN restores the effects of RNF126 silencing on cell proliferation, metastasis, and tumor formation in bladder cancer cells.

CELL DEATH & DISEASE (2021)

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Article Pharmacology & Pharmacy

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

Xiangjin Zheng et al.

Summary: GBM is a deadly form of advanced glioma with no effective treatment currently available. Sinomenine derivative SW33 shows promising antitumor activity against GBM by regulating PI3K/AKT and AMPK signaling pathways, and inducing autophagy as well. SW33 appears to be a safe and effective drug for GBM treatment.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

Atractylodin inhibited the migration and induced autophagy in cholangiocarcinoma cells via PI3K/AKT/mTOR and p38MAPK signalling pathways

Bishwanath Acharya et al.

Summary: Atractylodin inhibits proliferation and induces autophagy in cholangiocarcinoma cells by regulating the PI3K/AKT/mTOR and p38MAPK signaling pathways.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Role of Androgens and Androgen Receptor in Human Bladder Cancer

Elizabeth Martinez-Rojo et al.

Summary: Bladder cancer is a common neoplasm that mainly affects men, with risk factors including smoking and exposure to chemicals. The androgen receptor has been shown to play a significant role in the initiation and development of bladder cancer.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites

Robert C. Tuckey et al.

Summary: DHCR7 plays a crucial role in cholesterol biosynthesis. This study investigated the effects of various metabolites on DHCR7, with some shown to inhibit DHCR7 activity while others confirmed as substrates. This demonstrates the complex regulation of cholesterol metabolism and the potential therapeutic implications.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Pharmacology & Pharmacy