Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation

By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity during pluripotent reprogramming and oncogenic transformation.

Automated summary

By analyzing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell level, Huyghe et al identified two key transcription factors, Bcl11b and Atoh8, that control cell plasticity during pluripotent reprogramming and oncogenic transformation.