Modeling brain disorders using transplanted organoids: Beyond the short circuit

Human cortical organoids transplanted into the somatosensory cortex of rats integrate into the host neural circuits, receive inputs from host cells, and can produce behavioral responses. In a publication in Nature, Revah et al.(1) highlight the potential of this platform for modeling circuit defects associated with neurodevelopmental disorders.

Automated summary

Human cortical organoids transplanted into rats' somatosensory cortex can integrate into the host neural circuits, receive inputs from host cells, and produce behavioral responses. This study highlights the potential of this platform for modeling circuit defects associated with neurodevelopmental disorders.