4.7 Article

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis

Rui Su et al.

Summary: METTL16 has dual functions as an m(6)A writer in the nucleus and a translation facilitator in the cytosol, promoting translation through direct interactions with ribosomal RNAs and eukaryotic initiation factors.

NATURE CELL BIOLOGY (2022)

Article Biochemistry & Molecular Biology

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Ying Qing et al.

Summary: R-2-hydroxyglutarate (R-2HG) inhibits aerobic glycolysis in leukemia cells by targeting RNA modification, highlighting the therapeutic potential of targeting cancer epitranscriptomics and metabolism. This study reveals previously unrecognized effects of R-2HG on leukemia cells, providing insights into novel treatments for cancer.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova et al.

Summary: The study identified a highly potent and selective catalytic inhibitor of METTL3, STM2457, which shows potential therapeutic value in treating AML. Treatment with this inhibitor leads to reduced AML growth, increased differentiation and apoptosis, and decreased m(6)A levels on leukemogenic mRNAs. In vivo pharmacological inhibition of METTL3 results in impaired engraftment and prolonged survival in mouse models of AML.

NATURE (2021)

Article Genetics & Heredity

Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia

Zhimin Gu et al.

Summary: MPHOSPH8 loss inhibits the development of acute myeloid leukemia by reactivating LINE-1 retrotransposons, which induces DNA damage response and cell cycle exit in AML cells. The study also shows that AML oncogenic mutations promote L1 suppression, and enhanced L1 silencing is associated with poor prognosis in human AML.

NATURE GENETICS (2021)

Review Hematology

RNA modifications in hematopoietic malignancies: a new research frontier

Ying Qing et al.

Summary: Protein-coding and noncoding RNAs can undergo various chemical modifications to coordinate gene expression during hematopoietic differentiation and development; dysregulation of RNA modification modulators can drive hematopoietic malignancies; targeting these dysregulated modulators shows therapeutic potential for the treatment of hematopoietic malignancies.
Article Hematology

A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication

Yue Sheng et al.

Summary: YTHDC1 functions as a nuclear m(6)A reader in RNA metabolism regulation, with its overexpression shown in AML. Genetic deletion of Ythdc1 blocks AML development and maintenance, as well as LSCs self-renewal. YTHDC1 also plays a role in normal hematopoiesis and HSPC maintenance, with haploinsufficiency reducing LSCs self-renewal in vivo.
Article Oncology

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

Yuanming Cheng et al.

Summary: The study revealed the crucial role of m(6)A in myeloid leukemia, where it maintains cell survival and the undifferentiated state necessary for leukemia maintenance through the formation of nuclear YTHDC1-m(6)A condensates.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

Evolution of Methyltransferase-Like (METTL) Proteins in Metazoa: A Complex Gene Family Involved in Epitranscriptomic Regulation ana Other Epigenetic Processes

Juliet M. Wong et al.

Summary: The study investigates the evolutionary mechanisms of 33 individual METTL proteins in animals, revealing that they are widely distributed in the animal kingdom and mostly originated early in metazoan evolution. Each METTL lineage originated from a single independent ancestor, forming monophyletic clades, indicating strong selective constraints driving their specialization. However, nucleoside-modifying and protein-modifying METTLs did not form unique monophyletic clades, and showed differences in their rates of evolution.

MOLECULAR BIOLOGY AND EVOLUTION (2021)

Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

Article Multidisciplinary Sciences

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

Ina Yoon et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Mechanistic insights into m6A modification of U6 snRNA by human METTL16

Tomohiko Aoyama et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su et al.

Article Biochemistry & Molecular Biology

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

Katelyn A. Doxtader et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development

Mateusz Mendel et al.

MOLECULAR CELL (2018)

Article Multidisciplinary Sciences

m6A modulates haematopoietic stem and progenitor cell specification

Chunxia Zhang et al.

NATURE (2017)

Article Multidisciplinary Sciences

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

Isaia Barbieri et al.

NATURE (2017)

Article Multidisciplinary Sciences

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

Ayuna Hattori et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Defining a Cancer Dependency Map

Aviad Tsherniak et al.

Article Biochemistry & Molecular Biology

The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention

Kathryn E. Pendleton et al.

Review Hematology

Therapeutic targeting of acute myeloid leukemia stem cells

Daniel A. Pollyea et al.

Article Biotechnology & Applied Microbiology

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

Jessica A. Brown et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Xi Jiang et al.

NATURE COMMUNICATIONS (2016)

Review Cell Biology

Metabolic pathways promoting cancer cell survival and growth

Lindsey K. Boroughs et al.

NATURE CELL BIOLOGY (2015)

Review Medicine, General & Internal

Acute Myeloid Leukemia

Hartmut Doehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Letter Biochemical Research Methods

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana et al.

NATURE METHODS (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

Martje Toenjes et al.

NATURE MEDICINE (2013)

Article Biochemical Research Methods

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li et al.

BMC BIOINFORMATICS (2011)

Article Biochemical Research Methods

Uncovering the Human Methyltransferasome

Tanya C. Petrossian et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Review Oncology

EPIGENETICS AND GENETICS Leukaemogenesis: more than mutant genes

Jianjun Chen et al.

NATURE REVIEWS CANCER (2010)

Article Multidisciplinary Sciences

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

Eric Campeau et al.

PLOS ONE (2009)

Article Oncology

Therapeutic implications of leukemia stem cell development

Matthew C. Stubbs et al.

CLINICAL CANCER RESEARCH (2007)

Article Multidisciplinary Sciences

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9

Andrei V. Krivtsov et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

Ming Yan et al.

NATURE MEDICINE (2006)

Article Nutrition & Dietetics

Branched-chain amino acids: Enzyme and substrate regulation

JT Brosnan et al.

JOURNAL OF NUTRITION (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Lentivirus-delivered stable gene silencing by RNAi in primary cells

SA Stewart et al.