Uncoupling of energy production

Mitochondrial genetic diseases are a very diverse group of conditions. A recent report by Mootha and colleagues in NEJM describes the underlying genetic defect and clinical findings in monozygotic twins with uncoupling of ATP production.

Automated summary

This article discusses the diversity of mitochondrial genetic diseases and presents the study findings on monozygotic twins, revealing the genetic defect of uncoupling ATP production and its clinical manifestations.