4.8 Editorial Material

The Achilles heel of TNBCs Ferroptosis heterogeneity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

Fan Yang et al.

Summary: By integrating multiomics data, this study revealed the ferroptosis landscape of TNBC and proposed an innovative immunotherapy combination strategy for refractory LAR tumors.

CELL METABOLISM (2022)

Article Immunology

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity

Pengchong Li et al.

Summary: This study identifies a role for GPX4-regulated ferroptosis in neutrophils from SLE patients, triggered by interferons and autoreactive antibodies, contributing to lupus pathogenesis. The mechanism involves enhanced binding of a transcriptional repressor to the Gpx4 promoter leading to elevated lipid-reactive oxygen species. Neutrophil ferroptosis is shown to be a significant driver of neutropenia in SLE and heavily contributes to disease manifestations.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Yilong Zou et al.

NATURE (2020)

Review Cell Biology

The Metabolic Underpinnings of Ferroptosis

Jiashuo Zheng et al.

CELL METABOLISM (2020)

Article Chemistry, Multidisciplinary

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

John K. Eaton et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Pharmacology & Pharmacy

The Role of Ferroptosis in Cancer Development and Treatment Response

Bin Lu et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Oncology

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Giampaolo Bianchini et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)