☆ 4.7 Editorial Material

Making gut microbiomes from scratch

CELL HOST & MICROBE (2022)

The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping

Benjamin S. Beresford-Jones et al.

Summary: This study constructed the Mouse Gastrointestinal Bacteria Catalogue (MGBC) to identify functionally equivalent taxa between the gut microbiotas of humans and mice. It also provided a publicly deposited collection of bacterial isolates to facilitate experimental investigation of individual commensal bacteria functions.

CELL HOST & MICROBE (2022)

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Article Biochemistry & Molecular Biology

Design, construction, and in vivo augmentation of a complex gut microbiome

Alice G. Cheng et al.

Summary: Efforts have been made to model the human gut microbiome in mice, leading to insights into host-microbe interactions. In this study, a defined community of 104 bacterial species from the human gut microbiota was constructed and characterized. New species were identified and added to the community, resulting in increased stability and colonization resistance against pathogenic Escherichia coli. This consortium enables a mechanistic investigation of species and genes on microbiome-associated phenotypes.

CELL (2022)

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Article Microbiology

Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities

Afrizal Afrizal et al.

Summary: Microbiome research benefits from an extensive collection of cultured intestinal bacteria from mammalian hosts. In this study, the mouse intestinal bacterial collection was expanded, providing taxonomically described strains that support metagenome-educated prediction of synthetic communities and functional studies. The collection also enabled the improvement of a mouse microbiota model and identified microbiomes associated with colitis resistance or susceptibility.

CELL HOST & MICROBE (2022)

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Article Biotechnology & Applied Microbiology

A unified catalog of 204,938 reference genomes from the human gut microbiome

Alexandre Almeida et al.

Summary: The Unified Human Gastrointestinal Genome (UHGG) and Protein (UHGP) collections include a large number of non-redundant genomes and protein sequences, which are crucial for studying the relationship between genotypes and phenotypes in the human gut microbiome.

NATURE BIOTECHNOLOGY (2021)

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Article Microbiology

Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium

Sandrine Brugiroux et al.

NATURE MICROBIOLOGY (2017)

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Making gut microbiomes from scratch

相关参考文献

The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping

Design, construction, and in vivo augmentation of a complex gut microbiome

Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities

A unified catalog of 204,938 reference genomes from the human gut microbiome

Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium

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