4.4 Review

Understanding and targeting anoikis in metastasis for cancer therapies

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Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a major cause of cancer-related deaths in the United States. Surgical resection is the best treatment option, but only a small percentage of patients are eligible. Recurrence and metastasis are the main reasons for mortality. A monoclonal antibody named TAB004 has been developed to target tumor-associated MUC1 (tMUC1), which is expressed in over 80% of PDAs. Treatment with TAB004 has shown significant effects in reducing colony-forming potential in PDA cells and inducing cell death. The mechanism involves disruption of cellular integrity, activation of ER stress and anoikis, and inhibition of oncogenic signaling pathways. TAB004 also exhibited promising results in mouse models, indicating its potential as a prophylactic agent to prevent tumor relapse, metastasis, and increase the efficacy of chemotherapy.

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