期刊
CELL AND TISSUE RESEARCH
卷 391, 期 1, 页码 19-42出版社
SPRINGER
DOI: 10.1007/s00441-022-03707-9
关键词
Olfaction; Androgens; Estrogens; Steroidogenesis; Progesterone; Receptors
类别
This article reviews important findings about sex steroid metabolism in the mouse olfactory system and suggests potential areas for further research. The expression, distribution, and biological activity of steroidogenic enzymes, sex steroid receptors, and relevant proteins are summarized, along with their potential impact on early olfactory processing.
Sex steroid hormones influence olfactory-mediated social behaviors, and it is generally hypothesized that these effects result from circulating hormones and/or neurosteroids synthesized in the brain. However, it is unclear whether sex steroid hormones are synthesized in the olfactory epithelium or the olfactory bulb, and if they can modulate the activity of the olfactory sensory neurons. Here, we review important discoveries related to the metabolism of sex steroids in the mouse olfactory epithelium and olfactory bulb, along with potential areas of future research. We summarize current knowledge regarding the expression, neuroanatomical distribution, and biological activity of the steroidogenic enzymes, sex steroid receptors, and proteins that are important to the metabolism of these hormones and reflect on their potential to influence early olfactory processing. We also review evidence related to the effects of sex steroid hormones on the development and activity of olfactory sensory neurons. By better understanding how these hormones are metabolized and how they act both at the periphery and olfactory bulb level, we can better appreciate the complexity of the olfactory system and discover potential similarities and differences in early olfactory processing between sexes.
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