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FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury
Monica Chang-Panesso et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
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MOLECULAR CELL (2019)
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SCIENCE (2019)
Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates
Leigh Goedeke et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
Irene Hernando-Herraez et al.
NATURE COMMUNICATIONS (2019)
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Miguel A. Munoz-Lorente et al.
NATURE COMMUNICATIONS (2019)
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Nicholas J. W. Rattray et al.
NATURE COMMUNICATIONS (2019)
Identification and characterization of Cardiac Glycosides as senolytic compounds
Francisco Triana-Martinez et al.
NATURE COMMUNICATIONS (2019)
Biological Functions of Autophagy Genes: A Disease Perspective
Beth Levine et al.
CELL (2019)
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Jamie N. Justice et al.
EBIOMEDICINE (2019)
Mitochondria-Targeted Drugs
Roman A. Zinovkin et al.
CURRENT MOLECULAR PHARMACOLOGY (2019)
Giant tortoise genomes provide insights into longevity and age-related disease
Victor Quesada et al.
NATURE ECOLOGY & EVOLUTION (2019)
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy
Tugsan Tezil et al.
NPJ AGING AND MECHANISMS OF DISEASE (2019)
Unmasking senescence: context-dependent effects of SASP in cancer
Douglas V. Faget et al.
NATURE REVIEWS CANCER (2019)
Defining Adult Stem Cells by Function, not by Phenotype
Hans Clevers et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)
Senolytics improve physical function and increase lifespan in old age
Ming Xu et al.
NATURE MEDICINE (2018)
The gut microbiota influences anticancer immunosurveillance and general health
Bertrand Routy et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Steve Horvath et al.
NATURE REVIEWS GENETICS (2018)
The coming of age of chaperone-mediated autophagy
Susmita Kaushik et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Spermidine in health and disease
Frank Madeo et al.
SCIENCE (2018)
TORC1 inhibition enhances immune function and reduces infections in the elderly
Joan B. Mannick et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo
Markus C. Doeser et al.
STEM CELLS (2018)
Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages
Smitha Krishnan et al.
CELL REPORTS (2018)
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
Juan Manuel Povedano et al.
ELIFE (2018)
Mouse Models to Disentangle the Hallmarks of Human Aging
Alicia R. Folgueras et al.
CIRCULATION RESEARCH (2018)
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
Alvaro F. Fernandez et al.
NATURE (2018)
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
J. J. McNeil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh et al.
EBIOMEDICINE (2018)
Somatic mutant clones colonize the human esophagus with age
Inigo Martincorena et al.
SCIENCE (2018)
Fine-tuning PERK signaling for neuroprotection
Mark Halliday et al.
JOURNAL OF NEUROCHEMISTRY (2017)
Activation-Induced Autophagy Is Preserved in CD4+T-Cells in Familial Longevity
Yotam Raz et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2017)
Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial
Paul M. Ridker et al.
LANCET (2017)
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
Joseph M. Castellano et al.
NATURE (2017)
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
S. Jaiswal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Caloric restriction improves health and survival of rhesus monkeys
Julie A. Mattison et al.
NATURE COMMUNICATIONS (2017)
Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice
Floris Fransen et al.
FRONTIERS IN IMMUNOLOGY (2017)
Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency
Brian Lin et al.
CELL STEM CELL (2017)
Impact of intermittent fasting on health and disease processes
Mark P. Mattson et al.
AGEING RESEARCH REVIEWS (2017)
Plasticity in the lung: making and breaking cell identity
Purushothama Rao Tata et al.
DEVELOPMENT (2017)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Yi Zhu et al.
AGING CELL (2016)
Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia
Christian Bar et al.
BLOOD (2016)
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Federico Pietrocola et al.
CANCER CELL (2016)
Whole-Genome Sequencing of a Healthy Aging Cohort
Galina A. Erikson et al.
CELL (2016)
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Alejandro Ocampo et al.
CELL (2016)
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Sarah J. Mitchell et al.
CELL METABOLISM (2016)
Gut Microbiota and Extreme Longevity
Elena Biagi et al.
CURRENT BIOLOGY (2016)
Is Senescence Reversible?
Shweta Chakradeo et al.
CURRENT DRUG TARGETS (2016)
Tissue-specific mutation accumulation in human adult stem cells during life
Francis Blokzijl et al.
NATURE (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker et al.
NATURE (2016)
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg et al.
NATURE MEDICINE (2016)
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Michael S. Bonkowski et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Lluc Mosteiro et al.
SCIENCE (2016)
A Disease or Not a Disease? Aging As a Pathology
Timothy V. Gladyshev et al.
TRENDS IN MOLECULAR MEDICINE (2016)
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
Justin Rebo et al.
NATURE COMMUNICATIONS (2016)
In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury
Xiang Gao et al.
SCIENTIFIC REPORTS (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity
Cathy Slack et al.
CELL (2015)
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
Federico Pietrocola et al.
CELL METABOLISM (2015)
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Yun-Hee Youm et al.
NATURE MEDICINE (2015)
beta 2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Lucas K. Smith et al.
NATURE MEDICINE (2015)
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention
Andrew C. Chen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Exogenous Hsp70 delays senescence and improves cognitive function in aging mice
Natalia V. Bobkova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
Elizabeth H. Blackburn et al.
SCIENCE (2015)
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
Mary Mohrin et al.
SCIENCE (2015)
Collagenase-resistant collagen promotes mouse aging and vascular cell senescence
Faran Vafaie et al.
AGING CELL (2014)
IGF-I regulates the age-dependent signaling peptide humanin
Changhan Lee et al.
AGING CELL (2014)
Progeria: A Paradigm for Translational Medicine
Leslie B. Gordon et al.
CELL (2014)
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
Brian J. North et al.
EMBO JOURNAL (2014)
Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing
Laura C. Greaves et al.
PLOS GENETICS (2014)
Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling
Edward Owusu-Ansah et al.
CELL (2013)
Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster
Eleni N. Tsakiri et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Overexpression of Atg5 in mice activates autophagy and extends lifespan
Jong-Ok Pyo et al.
NATURE COMMUNICATIONS (2013)
SIRT3 Reverses Aging-Associated Degeneration
Katharine Brown et al.
CELL REPORTS (2013)
DNA methylation age of human tissues and cell types
Steve Horvath
GENOME BIOLOGY (2013)
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Atsuhiko T. Naito et al.
CELL (2012)
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
Bruno Bernardes de Jesus et al.
EMBO MOLECULAR MEDICINE (2012)
Inhibitory effect of dietary lipids on chaperone-mediated autophagy
Jose Antonio Rodriguez-Navarro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis
Kimberly Larson et al.
PLOS GENETICS (2012)
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix
Hae Ri Choi et al.
AGING CELL (2011)
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
Vladimir N. Anisimov et al.
CELL CYCLE (2011)
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Mariela Jaskelioff et al.
NATURE (2011)
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Saul A. Villeda et al.
NATURE (2011)
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Paula Martinez et al.
NATURE REVIEWS CANCER (2011)
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
Marta M. Lipinski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells
Rosa M. Marion et al.
CELL STEM CELL (2009)
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Han Li et al.
NATURE (2009)
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
Antonia Tomas-Loba et al.
CELL (2008)
The epigenetic regulation of mammalian telomeres
Maria A. Blasco
NATURE REVIEWS GENETICS (2007)
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
Kazutoshi Takahashi et al.
CELL (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
Telomeres and human disease: Ageing, cancer and beyond
MA Blasco
NATURE REVIEWS GENETICS (2005)