Photocatalytic One-Pot Synthesis of Quinazolinone Under Ambient Conditions

A novel photocatalytic cyclization reaction was developed for the synthesis of quinazolinones from o-aminobenzamides and in-situ generated aldehydes from alcohols using 9-fluorenone as the photocatalyst through a one-pot process. Furthermore, alcohols are perfect alternatives to aldehydes due to some unique advantages, such as being green, less toxic, available, and economical. The present protocol showed good tolerance for various substrates and could afford a range of quinazolinones (29 examples) up to 91% under ambient conditions. [GRAPHICS]

Automated summary

A novel photocatalytic cyclization reaction using 9-fluorenone as the photocatalyst has been developed for the synthesis of quinazolinones from o-aminobenzamides and in-situ generated aldehydes from alcohols. Furthermore, alcohols are found to be suitable alternatives to aldehydes due to their green, less toxic, available, and economical nature. The protocol showed good tolerance for various substrates and achieved high yields (up to 91%) of quinazolinones under ambient conditions.