期刊
CARDIOVASCULAR DRUGS AND THERAPY
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s10557-023-07426-3
关键词
Diabetic cardiomyopathy; Bicyclol; Inflammation; Oxidative stress; MAPK; NF-kappa B
Bicyclol, a traditional Chinese medicine, shows promising therapeutic effects in diabetic cardiomyopathy (DCM) by inhibiting inflammation and oxidative stress through the MAPK and NF-kappa B pathways.
Purpose Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes. Inflammation and oxidative stress play important roles in DCM development. Bicyclol is a hepatoprotective drug in China that exerts anti-inflammatory effects by inhibiting the MAPK and NF-kappa B pathways to prevent obesity-induced cardiomyopathy. Our purpose was to explore the effect and mechanism of bicyclol on DCM.Methods A type 1 diabetes mouse model was established using C57BL/6 mice by intraperitoneal injection of STZ. The therapeutic effect of bicyclol was evaluated in both heart tissues of diabetic mice and high concentration of glucose (HG)-stimulated H9c2 cells.Results We showed that bicyclol significantly attenuated diabetes-induced cardiac hypertrophy and fibrosis, which is accompanied by the preservation of cardiac function in mice. In addition, bicyclol exhibited anti-inflammatory and anti-oxidative effects both in vitro and in vivo. Furthermore, bicyclol inhibited the hyperglycemia-induced activation of MAPKs and NF-kappa B pathways, while upregulating the Nrf-2/HO-1 pathway to exhibit protective effects.Conclusion Our data indicate that bicyclol could be a promising cardioprotective agent in the treatment of DCM.
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