期刊
CARBON
卷 201, 期 -, 页码 805-814出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2022.09.052
关键词
Near-infrared fluorescent carbon dots; Super-small size; Renal clearance; Renal imaging
Successful preparation of NIR-CDs for real-time renal imaging was achieved, demonstrating high-efficiency renal clearance and reversible clearance in mice models, offering a new tool for imaging analysis of impaired kidney function.
Real-time renal imaging is indispensable for monitoring kidney-related disease processes and evaluating the nephrotoxicity of nanoprobes. Owing to their small size, tunable photoluminescence properties, and low biotoxicity, carbon dots (CDs) are widely employed as nanoprobes for imaging-guided disease diagnosis. However, the preparation of near-infrared CDs is a stupendous challenging. Here, CDs with near-infrared fluorescence (NIR-CDs) were prepared by one-pot pyrolysis and were comprehensively evaluated for real-time renal imaging. The NIR-CDs possessed super-small size (1.8 +/- 0.2 nm) and high quantum yield (14.3% in aqueous solution) at 696 nm. NIR-CDs exhibited high-efficiency renal clearance at 24 h post-treatment (97.47-99.27% ID) via glomerular filtration. The irreversible clearance of NIR-CDs enables effective real-time monitoring of kidney function in the normal and acute kidney injury (AKI) mouse models. Consequently, NIR-CDs can be utilized for imaging analyses of impaired kidney function, pioneering a serviceable guideline for neoapplications of NIR-CDs.
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