期刊
CARBOHYDRATE RESEARCH
卷 522, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2022.108679
关键词
NAG; Biomass conversion; Lewis acid; Reaction pathway
资金
- Tianjin science and tech-nology commission
- [18JCYBJC87200]
In this study, a mild and efficient method for the synthesis of 3A5AF from NAG was reported. The influence of solvent, temperature, and additive on the catalytic performance was studied. By screening suitable catalysts and optimizing reaction conditions, a higher yield was obtained.
3-Acetamido-5-acetylfuran(3A5AF) is a nitrogen-containing fine chemical and has broad application prospects and high research value. Herein, we report a mild and efficient method for the synthesis of 3A5AF from N-acetyl-D-glucosamine (NAG). The influence of solvent, temperature and additive on the catalytic performance was also studied. The Lewis acids with high catalytic efficiency have been smoothly screened. The highest yield (41.57%) of 3A5AF was obtained in the presence of B2O3 and MgCl2.6H2O at 180 degrees C for 60 min under normal atmospheric conditions. The reaction pathway was explored by LC-MS, 1H NMR, 13C NMR and FT-IR spectra. Compared with the microwave method and hydrothermal method, the optimized reaction condition was relatively mild. Moreover, the catalyst MgCl2.6H2O is low-cost and environmentally friendly.
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