Biocompatible scaffolds constructed by chondroitin sulfate microspheres conjugated 3D-printed frameworks for bone repair

Article Endocrinology & Metabolism

Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies

P. Tharabenjasin et al.

Summary: The meta-analysis confirmed a significant protective effect of OPG polymorphisms on fractures in older adults, especially in postmenopausal women, those aged >= 60, and Western populations.

OSTEOPOROSIS INTERNATIONAL (2022)

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Article Engineering, Biomedical

Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels

Junxiang Hao et al.

Summary: This study proposes a novel strategy of bone regeneration units (BRUs) by combining decalcified bone matrix (DBM) and vascular endothelial growth factor (VEGF) in microgels, creating an accurate biomimetic osteoinductive microenvironment. The physicochemical properties of microgels can be controlled, promoting adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro and reliable bone regeneration in vivo. By integrating BRUs with a DBM framework, bone tissue with desired 3D morphology is successfully regenerated and large-sized bone defects are effectively repaired.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Multidisciplinary

DLP fabricating of precision GelMA/HAp porous composite scaffold for bone tissue engineering application

Ping Song et al.

Summary: This study aimed to prepare high-precision GelMA/HAp composite scaffolds using digital light processing (DLP) printing for bone repair. GelMA hydrogels with adjustable properties were synthesized, and suitable dispersants were selected to reduce the agglomeration of HAp. The printed composite scaffolds with excellent mechanical strength showed promotion of osteoblast adhesion, proliferation, and differentiation in vitro. In vivo experiments on rabbit skull defects demonstrated the ability of the composite scaffolds to accelerate new bone formation. The GelMA/HAp porous composite scaffolds fabricated by composite inks with good printability, mechanical properties, and osteogenic activity have great potential in bone repair applications.

COMPOSITES PART B-ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

3D Printing Hydrogel Scaffolds with Nanohydroxyapatite Gradient to Effectively Repair Osteochondral Defects in Rats

Hui Zhang et al.

Summary: In this study, a 3D printed gradient hydrogel scaffold with nanohydroxyapatite (nHA) gradients was designed to promote osteochondral (OC) defect repair. The results showed that the bone marrow stromal cells (BMSCs)-loaded gradient scaffolds demonstrated superior repair outcomes compared to other scaffolds, indicating great potential for future practical applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

3D printed micro-chambers carrying stem cell spheroids and pro-proliferative growth factors for bone tissue regeneration

Jinkyu Lee et al.

Summary: The 3D-printed polycaprolactone micro-chamber effectively delivers human adipose-derived stem cell spheroids with increased viability and proliferation. Coating the chamber with 500 ng of PDGF and immobilizing 50 ng of BMP-2 within the spheroids as a dual growth factor delivery system enhances osteogenic differentiation, leading to improved bone regeneration in vivo.

BIOFABRICATION (2021)

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Article Engineering, Biomedical

Dual 3D printing for vascularized bone tissue regeneration

Sung Yun Hann et al.

Summary: The development of vascular networks is crucial for tissue fabrication in regenerative medicine. 3D printing vascularized bone has gained attention due to bone disorders, but challenges persist due to the need for nanoscale precision. A novel 3D printing approach was combined with biocompatible materials to enhance vascular growth and tissue bioactivity.

ACTA BIOMATERIALIA (2021)

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Article Biochemistry & Molecular Biology

A novel hydrogel scaffold contained bioactive glass nanowhisker (BGnW) for osteogenic differentiation of human mesenchymal stem cells (hMSCs) in vitro

Esmat Azizipour et al.

Summary: Employing hydrogels with bioactive glass nanowhiskers for bone tissue repair showed successful induction of hMSCs differentiation into osteogenic lineage and biomineralization. Cell viability assays confirmed biocompatibility and increased proliferation with BGnW incorporation. Molecular investigations revealed elevated osteogenic markers level, suggesting Gel-Glu-Col/BGnW as a potential candidate for bone tissue regeneration.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Biomedical

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

Limei Li et al.

Summary: This study developed nano-hydroxyapatite/resveratrol/chitosan composite microspheres for promoting bone formation and inflammation reduction. The controlled release of resveratrol improved cell adhesion, proliferation, and osteogenic differentiation, leading to enhanced bone regeneration and fracture healing in osteoporotic conditions, indicating promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Engineering Single-Atomic Iron-Catalyst-Integrated 3D-Printed Bioscaffolds for Osteosarcoma Destruction with Antibacterial and Bone Defect Regeneration Bioactivity

Liying Wang et al.

Summary: The study introduces a scaffold engineering strategy that integrates highly active single-atomic iron catalysts into bioactive glass scaffold for effective osteosarcoma treatment and bacterial sterilization. The localized hyperthermia-reinforced nanocatalytic therapeutics offer efficient osteosarcoma ablation while preventing chronic osteomyelitis. This approach provides a clinically feasible strategy for overall osteosarcoma therapeutics, bacterial inhibition, and tissue regeneration.

ADVANCED MATERIALS (2021)

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Article Nanoscience & Nanotechnology