4.7 Article

Salecan confers anti-inflammatory effects in liver injury via regulating gut microbiota and its metabolites

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Nutrition & Dietetics

Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice

Vuong Vu et al.

Summary: This study showed that modulating gut bacteria with beta-glucan and probiotics improved obesity-associated colitis, with synbiotics having a stronger and broader effect compared to individual treatments. Synbiotics were able to promote the growth of both indigenous and supplemented probiotic strains, resulting in improved gut health.

EUROPEAN JOURNAL OF NUTRITION (2022)

Article Cell Biology

Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells

Wei Zheng et al.

Summary: Liver fibrosis is a major challenge in global health, and scientists are actively searching for drugs to alleviate it. Uridine has shown effectiveness in reducing collagen accumulation, improving liver cell activity, alleviating liver injury, and reducing risk factors caused by hepatic stellate cell activation in experimental studies.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Article Oncology

Knockdown of RSPH14 inhibits proliferation, migration, and invasion and promotes apoptosis of hepatocellular carcinoma via RelA

Dawei Yuan et al.

Summary: The high expression of RSPH14 in hepatocellular carcinoma (HCC) is associated with poor prognosis. Knockdown of RSPH14 can inhibit cell proliferation, migration, and invasion, and promote apoptosis of HCC cells by inhibiting the expression of RelA. RSPH14 may be a potential new treatment target for HCC.

CANCER CELL INTERNATIONAL (2022)

Article Biology

Variants of beta-glucan polysaccharides downregulate autoimmune inflammation

Cecilia Fahlquist-Hagert et al.

Summary: This study investigated the effects of beta-glucan polysaccharides in arthritis and as regulators of psoriasis and PsA-like symptoms in mice. The results showed that beta-glucans down-regulated disease in mice and the protection was dependent on macrophage mannose receptor. Furthermore, beta-glucans could ameliorate PsA-like symptoms, suggesting a potential clinical treatment option.

COMMUNICATIONS BIOLOGY (2022)

Article Nutrition & Dietetics

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Baichang Xu et al.

Summary: This study found that Broussonetia papyrifera polysaccharide (BPP) can protect the liver from acetaminophen-induced injury and improve intestinal flora disorder. The hepatoprotective effect of BPP is mediated by intestinal flora.

NUTRIENTS (2022)

Article Chemistry, Applied

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Dominik Rotrekl et al.

Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.

CARBOHYDRATE POLYMERS (2021)

Article Biochemistry & Molecular Biology

Anti-inflammatory effects of β-1,3-1,6-glucan derived from black yeast Aureobasidium pullulans in RAW264.7 cells

Huiwon No et al.

Summary: The low-molecular-weight A. pullulans-fermented beta-D-glucan showed potential as an immune modulator by reducing the release of inflammatory mediators and modulating key signaling pathways in LPS-stimulated macrophages.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Multidisciplinary Sciences

Fecal transplantation alleviates acute liver injury in mice through regulating Treg/Th17 cytokines balance

Yongmei Liu et al.

Summary: The study found that changes in intestinal microecology during acute liver failure directly impact the occurrence and development of the disease. Fecal microbiota transplantation (FMT) can restore some bacterial flora, reduce the expression of inflammatory factors, improve liver damage, providing new insights and methods for treating ALF.

SCIENTIFIC REPORTS (2021)

Article Medicine, Research & Experimental

Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS

Qiongmei Xu et al.

Summary: The study utilized Dicliptera chinensis polysaccharide (DCP) to intervene the NF-kappa B inflammatory pathway and Fas/FasL ligand system, effectively reducing liver injury through inflammation and apoptosis inhibition. This novel approach provides a new strategy for the clinical treatment of immune liver injury.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice

Minjie Chen et al.

Summary: Highland barley beta-glucan (HBBG) can relieve ulcerative colitis (UC) in mice by reducing the disease activity index (DAI) score, histopathological damage, and colonic atrophy, as well as increasing colonic myeloperoxidase (MPO) concentration. Additionally, HBBG can lower intestinal permeability, maintain the balance of proinflammatory and anti-inflammatory cytokines, and modulate the structure of the intestinal flora.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Anti-nociceptive effect of Portulaca oleracea L. ethanol extracts attenuated zymosan-induced mouse joint inflammation via inhibition of Nrf2 expression

Yunwu He et al.

Summary: The study aimed to investigate the effects of ethanol extracts from Portulaca oleracea L. (ePO) on joint inflammation and their underlying mechanisms. Results showed that ePO pre-treatment inhibited articular mechanical hyperalgesia and edema, improved pathological alternations by reducing inflammatory cells, regulated Nrf2-related proteins to inhibit oxidative stress, and attenuated joint inflammation by modulating the NLRP3 inflammasome and NF-kappa B activation.

INNATE IMMUNITY (2021)

Article Chemistry, Medicinal

Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

Zhi-Qing Chen et al.

Summary: The study demonstrated that pretreatment with breviscapine could significantly alleviate myocardial injury caused by CME, reduce myocardial inflammation and apoptosis, and improve cardiac function. However, when breviscapine was combined with LY294002, these protective effects were eliminated.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Nutrition & Dietetics

Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

Camille Houron et al.

Summary: The study suggests that pectin plays a positive role in non-alcoholic fatty liver disease (NAFLD) by affecting gut bacteria, with preventive and curative fecal microbiota transfer (FMT) having different mechanisms of action on NAFLD.

NUTRIENTS (2021)

Article Cell & Tissue Engineering

SPION-MSCs enhance therapeutic efficacy in sepsis by regulating MSC-expressed TRAF1-dependent macrophage polarization

Yujun Xu et al.

Summary: The study demonstrated that SPIONs did not affect the basic characteristics of MSCs and even promoted their survival in inflammatory conditions. SPION-MSCs enhanced the therapeutic efficacy of liver injury in sepsis animal models, with this protective effect being related to macrophages.

STEM CELL RESEARCH & THERAPY (2021)

Article Immunology

Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province

Bingsi Gao et al.

Summary: This study revealed alterations in the gut microbiota of patients with missed abortions, particularly with higher abundance of Actinobacteria compared to normal pregnant women. Significant differences were found in signaling pathways and metabolic pathways, as well as a higher detection rate of M. hominins in the control group compared to the MA group.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

Article Biology

Hepatoprotective effects of Cassiae Semen on mice with non-alcoholic fatty liver disease based on gut microbiota

Hanyan Luo et al.

Summary: The study shows that Cassiae Semen and its extracted components can protect against HFD-induced liver injury by ameliorating lipid accumulation, intestinal barrier damage, liver damage, and inflammation, and can also confer their pharmacological effects through fecal microbiome transplantation.

COMMUNICATIONS BIOLOGY (2021)

Review Cell Biology

Dietary Fiber: An Opportunity for a Global Control of Hyperlipidemia

Ying Nie et al.

Summary: This review article analyzed the structures, sources, and natures of different kinds of dietary fibers, as well as their relationship with lipid-lowering effects. It summarized the potential mechanisms and protective actions of dietary fibers in the treatment and prevention of hyperlipidemia, highlighting five major mechanisms responsible for their antihyperlipidemic benefits. Further investigations and more clinical evidence are needed to fully understand the underlying mechanisms of dietary fibers in exerting lipid-lowering effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Biochemistry & Molecular Biology

Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition

Yanjun Liu et al.

Summary: This study investigates the role of ethanolamine plasmalogen in Alzheimer's disease and metabolic diseases, providing insights into the mechanistic bases for these conditions. The findings suggest that ethanolamine plasmalogen deficiency may lead to the development of steatohepatitis and memory impairments, and restoring ethanolamine plasmalogen levels could prevent these diseases. The study reveals a potential therapeutic strategy for combating steatosis and memory impairments through modulation of plasmalogen levels.

REDOX BIOLOGY (2021)

Article Food Science & Technology

Source of gut microbiota determines oat β-glucan degradation and short chain fatty acid-producing pathway

Junying Bai et al.

Summary: This study investigated the effect of gut microbial source on oat beta-glucan metabolism by using mice and human fecal microbiota in an in vitro fermentation experiment. The main end products from gut microbial fermentation of beta-glucan were acetate, propionate, and butyrate, with differences in the main product between the mice and human groups. The data suggested that beta-glucan could be completely hydrolyzed by human fecal microbiota but not thoroughly degraded by mice fecal microbiota.

FOOD BIOSCIENCE (2021)

Article Chemistry, Applied

The bioavailability of soybean polysaccharides and their metabolites on gut microbiota in the simulator of the human intestinal microbial ecosystem (SHIME)

Pin Chen et al.

Summary: Soybean polysaccharides were found to be beneficial for gut microbiota in the SHIME, reducing pathogenic bacteria and promoting the growth of probiotics, ultimately contributing to gut health.

FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Hydrophilic Astaxanthin: PEGylated Astaxanthin Fights Diabetes by Enhancing the Solubility and Oral Absorbability

Yanjun Liu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Soluble beta-glucan salecan improves vaginal infection of Candida albicans in mice

Xiaqing Sun et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Immunology

Dietary and Microbial Determinants in Food Allergy

Emmanuel Stephen-Victor et al.

IMMUNITY (2020)

Article Biochemistry & Molecular Biology

Protective effects of a Lachnum polysaccharide against liver and kidney injury induced by lead exposure in mice

Guohua Hou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Biochemistry & Molecular Biology

Hepatoprotective effect of a polysaccharide from Radix Cyathulae officinalis Kuan against CCl4-induced acute liver injury in rat

Xianqun Meng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Review Biochemistry & Molecular Biology

A Concise Review on the Molecular Structure and Function Relationship of β-Glucan

Bin Du et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Food Science & Technology

Preventive effect of flavonoids from Wushan Shencha (Malus doumeri leaves) on CCl4-induced liver injury

Kai Zhu et al.

FOOD SCIENCE & NUTRITION (2019)

Article Agriculture, Multidisciplinary

Yeast β-Glucan Suppresses the Chronic Inflammation and Improves the Microenvironment in Adipose Tissues of ob/ob Mice

Yan Cao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Medicine, Research & Experimental

Cellular Mechanisms of Hepatoprotection Mediated by M2-Like Macrophages

Li Bai et al.

MEDICAL SCIENCE MONITOR (2018)

Review Biochemistry & Molecular Biology

A critical review on the impacts of beta-glucans on gut microbiota and human health

Muthukumaran Jayachandran et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

Article Nutrition & Dietetics

Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation

Sigrid E. M. Heinsbroek et al.

NUTRITION RESEARCH (2015)

Review Biochemistry & Molecular Biology

Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1

Sainkhuu Batbayar et al.

BIOMOLECULES & THERAPEUTICS (2012)

Article Gastroenterology & Hepatology

A mouse model of accelerated liver aging caused by a defect in DNA repair

Siobhan Q. Gregg et al.

HEPATOLOGY (2012)