4.7 Article

An electrochemical chiral sensor for amino acids based on cyclodextrin modified thiophene-based copolymer

期刊

CARBOHYDRATE POLYMERS
卷 297, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.120012

关键词

Cyclodextrin; Polythiophenes; Click chemistry; Chiral sensing

资金

  1. National Natural Science Foundation of China [21976131, 21922409]

向作者/读者索取更多资源

In this study, two series of thiophene-based copolymers with cyclodextrins (CDs) grafted on the side chain were synthesized to achieve efficient enantio-recognition of amino acids. The copolymers showed a reverse interaction preference for D- and L-isomers due to the different interaction modes of native and substituted CDs. The content of the CD block in the copolymer was found to affect the sensitivity and chiral selectivity of the electrochemical sensor.
Two series of thiophene-based copolymers with cyclodextrins (CDs) grafted on side chain (OH-beta-CD-P3HT and Ph-beta-CD-P3HT) were synthesized via click reaction, in which the pendant CDs and the polythiophenes (PTs) main chain afford stereo-selective interactions and high conductivity respectively. The copolymers have been employed to construct an electrochemical sensor to achieve efficient enantio-recognition for amino acids. The OH-beta-CD-P3HT and Ph-beta-CD-P3HT shows reverse interaction preference for D- and L-isomer due to the different interaction mode of native and substituted CDs with chiral guest. It is found that, higher content of block with CD in the copolymer favors lower LOD because of the specific inclusion abilities of CD, while lower content of block with CD is beneficial to chiral selectivity related to the higher structural flexibility of the polymer. The electrochemical sensor was also proven to be capable of determining the relative content of L- or D-isomer in an enantiomer pair.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据