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CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)
Targeting latency-associated peptide promotes antitumor immunity
Galina Gabriely et al.
SCIENCE IMMUNOLOGY (2017)
Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms
Daniel Bedinger et al.
MABS (2016)
TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair
L. Qiang et al.
ONCOGENE (2016)
Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling
Maria M. Villarreal et al.
BIOCHEMISTRY (2016)
Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer
Alessandra Metelli et al.
CANCER RESEARCH (2016)
TGF-β: the master regulator of fibrosis
Xiao-ming Meng et al.
NATURE REVIEWS NEPHROLOGY (2016)
Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma
Peter J. Cook et al.
NEURO-ONCOLOGY (2016)
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
Sebastien Viel et al.
SCIENCE SIGNALING (2016)
TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
Benjamin V. Park et al.
CANCER DISCOVERY (2016)
Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation
David T. Coleman et al.
ONCOTARGET (2016)
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
Sebastien Viel et al.
SCIENCE SIGNALING (2016)
TGFβ-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells
Y. Mu et al.
BRITISH JOURNAL OF CANCER (2015)
Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor beta by the monoclonal antibody fresolimumab (GC1008)
Mario E. Lacouture et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)
TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma
Naoki Oshimori et al.
CELL (2015)
Peripheral blood NK cells expressing HLA-G, IL-10 and TGF-β in healthy donors and breast cancer patients
Yekaterina O. Ostapchuk et al.
CELLULAR IMMUNOLOGY (2015)
A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer
G. Giaccone et al.
EUROPEAN JOURNAL OF CANCER (2015)
Role of IL-10 and TGF-β in melanoma
Arlina P. Wiguna et al.
EXPERIMENTAL DERMATOLOGY (2015)
TGF-β Antibody Uptake in Recurrent High-Grade Glioma Imaged with 89Zr-Fresolimumab PET
Martha W. den Hollander et al.
JOURNAL OF NUCLEAR MEDICINE (2015)
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo
Julia Cuende et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer
Jitka Y. Sagiv et al.
CELL REPORTS (2015)
Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer
Pamela Maris et al.
PLOS MEDICINE (2015)
TGF-β1-induced epitheal-mesenchymal transition promotes monocyte/macrophage properties in breast cancer cells
Joel Johansson et al.
FRONTIERS IN ONCOLOGY (2015)
Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study
Richard J. Kovacs et al.
CARDIOVASCULAR TOXICOLOGY (2015)
First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma
Jordi Rodon et al.
CLINICAL CANCER RESEARCH (2015)
Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion
Chiung-Nien Chen et al.
GASTRIC CANCER (2015)
Silibinin Prevents Prostate Cancer Cell-Mediated Differentiation of Naive Fibroblasts into Cancer-Associated Fibroblast Phenotype by Targeting TGF β2
Harold J. Ting et al.
MOLECULAR CARCINOGENESIS (2015)
Tumor-Derived Transforming Growth Factor-β is Critical for Tumor Progression and Evasion from Immune Surveillance
Zheng Li et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)
Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
Melissa Noack et al.
AUTOIMMUNITY REVIEWS (2014)
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
Y. Yu et al.
BRITISH JOURNAL OF CANCER (2014)
Defective TGF-β Signaling in Bone Marrow-Derived Cells Prevents Hedgehog-Induced Skin Tumors
Qipeng Fan et al.
CANCER RESEARCH (2014)
TGF-β1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells
Rajshri Singh et al.
CELLULAR SIGNALLING (2014)
A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancer
Allen Cohn et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts
Massimo Ammirante et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The Tumor Suppressor Smad4/DPC4 Is Regulated by Phosphorylations that Integrate FGF, Wnt, and TGF-β Signaling
Hadrien Demagny et al.
CELL REPORTS (2014)
Tumor suppressor NDRG2 tips the balance of oncogenic TGF-β via EMT inhibition in colorectal cancer
L. Shen et al.
ONCOGENESIS (2014)
Relationship of TGF-β1 and Smad7 expression with decreased dendritic cell infiltration in liver gastrointestinal cancer metastasis
Maya Gulubova et al.
APMIS (2013)
SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer
Nicholas I. Fleming et al.
CANCER RESEARCH (2013)
IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation
Chen-Si Lin et al.
CYTOKINE (2013)
Mutation of TGF-β receptor II facilitates human bladder cancer progression through altered TGF-β1 signaling pathway
Jing Bian et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Death Domain-associated Protein DAXX Promotes Ovarian Cancer Development and Chemoresistance
Wei-Wei Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Induction of myelodysplasia by myeloid-derived suppressor cells
Xianghong Chen et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Control of cell cycle transcription during G1 and S phases
Cosetta Bertoli et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
C. Eberlein et al.
ONCOGENE (2013)
Macrophage coculture enhanced invasion of gastric cancer cells via TGF-β and BMP pathways
Zhanlong Shen et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2013)
The roles of TGFβ in the tumour microenvironment
Michael Pickup et al.
NATURE REVIEWS CANCER (2013)
Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck
Kazuaki Chikamatsu et al.
CANCER SCIENCE (2012)
On the dual roles and polarized phenotypes of neutrophils in tumor development and progression
H. Piccard et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2012)
Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway
Yong Yang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils
Adebusola Alagbala Ajibade et al.
IMMUNITY (2012)
MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN
Yang Liu et al.
JOURNAL OF IMMUNOLOGY (2012)
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells
Sara M. Centuori et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2012)
TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy
Jeffrey P. Marcoe et al.
NATURE IMMUNOLOGY (2012)
TGFβ signalling in context
Joan Massague
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways
I. Keklikoglou et al.
ONCOGENE (2012)
TGF-β of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation
Xiao Yan Ni et al.
ONCOLOGY REPORTS (2012)
Inhibition of TGF-β/Smad Signaling by BAMBI Blocks Differentiation of Human Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts and Abolishes Their Protumor Effects
Lei Shangguan et al.
STEM CELLS (2012)
A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis
Stephanie Carnesecchi et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGFβ1 in Melanoma Enhances Tumor Infiltration and Immunosuppression
Nancy Diaz-Valdes et al.
CANCER RESEARCH (2011)
Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761
Erin C. Connolly et al.
CANCER RESEARCH (2011)
Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells
Purevdorj B. Olkhanud et al.
CANCER RESEARCH (2011)
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice
Jennifer Nancy Hahn et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Hydrolysable tannins of tropical almond show antifibrotic effects in TGF-β1-induced hepatic stellate cells
Hsin-Ying Chuang et al.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2011)
A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
Howard Trachtman et al.
KIDNEY INTERNATIONAL (2011)
Targeted therapy for high-grade glioma with the TGF-beta 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study
U. Bogdahn et al.
NEURO-ONCOLOGY (2011)
Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
Mark J. Anderton et al.
TOXICOLOGIC PATHOLOGY (2011)
A possible mechanism of impaired NK cytotoxicity in cancer patients: down-regulation of DAP10 by TGF-β1
June-Chul Lee et al.
TUMORI JOURNAL (2011)
Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor
Benjamin Toh et al.
PLOS BIOLOGY (2011)
Anti-Transforming Growth Factor β Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells
Zhaojing Zhong et al.
CLINICAL CANCER RESEARCH (2010)
Transforming growth factor beta (TGF-β) and inflammation in cancer
Brian Bierie et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2010)
Transforming Growth Factor-Beta Induces Senescence in Hepatocellular Carcinoma Cells and Inhibits Tumor Growth
Serif Senturk et al.
HEPATOLOGY (2010)
Role of TGF-β1, its receptor TGFβRII, and Smad proteins in the progression of colorectal cancer
Maya Gulubova et al.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2010)
Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-β Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer
Christina H. Stuelten et al.
PLOS ONE (2010)
Anti-CTLA-4 Antibody Therapy: Immune Monitoring During Clinical Development of a Novel Immunotherapy
Margaret K. Callahan et al.
SEMINARS IN ONCOLOGY (2010)
Connection between inflammation and carcinogenesis in gastrointestinal tract: Focus on TGF-β signaling
Suntaek Hong et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2010)
Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers
Logan C. Walker et al.
BREAST CANCER RESEARCH (2010)
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN
Zvi G. Fridlender et al.
CANCER CELL (2009)
Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
J. Nemunaitis et al.
CANCER GENE THERAPY (2009)
Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+ inducible regulatory T cells
Jinfang Zhu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-beta 1
Hequan Li et al.
JOURNAL OF IMMUNOLOGY (2009)
TGF-β repression of Id2 induces apoptosis in gut epithelial cells
Y. Cao et al.
ONCOGENE (2009)
Differential impact of TGF-β and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion
Hannelore Denys et al.
CANCER LETTERS (2008)
TGFβ-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2
Sneha Ramesh et al.
EMBO REPORTS (2008)
Axin and GSK3-beta control Smad3 protein stability and modulate TGF-beta signaling
Xing Guo et al.
GENES & DEVELOPMENT (2008)
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity
Irene Carmona-Cuenca et al.
JOURNAL OF HEPATOLOGY (2008)
TGF-β utilizes SMAD3 to inhibit CD16-mediated IFN-γ production and antibody-dependent cellular cytotoxicity in human NK cells
Rossana Trotta et al.
JOURNAL OF IMMUNOLOGY (2008)
Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-β signaling
X. Guo et al.
ONCOGENE (2008)
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Christian Gruetter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis
Xiao-Ling Wu et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Synergistic effect between EGF and TGF-β1 in inducing oncogenic properties of intestinal epithelial cells
S. Uttamsingh et al.
ONCOGENE (2008)
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
Yukiko Tone et al.
NATURE IMMUNOLOGY (2008)
TGF-β insensitive dendritic cells:: an efficient vaccine for murine prostate cancer
Fu-Li Wang et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2007)
Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis
A. R. Ramjaun et al.
ONCOGENE (2007)
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
Byung-Gyu Kim et al.
NATURE (2006)
A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes
J. Gotzmann et al.
ONCOGENE (2006)
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
DA Thomas et al.
CANCER CELL (2005)
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-β
CH Stuelten et al.
JOURNAL OF CELL SCIENCE (2005)
A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers
SK Halder et al.
NEOPLASIA (2005)
Role of transforming growth factor beta in human cancer
RL Elliott et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivoi
ML Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Integration of Smad and Forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
J Seoane et al.
CELL (2004)
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
NA Bhowmick et al.
SCIENCE (2004)
Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients
JC Lee et al.
JOURNAL OF IMMUNOLOGY (2004)
SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
M Uhl et al.
CANCER RESEARCH (2004)
TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
C Becker et al.
IMMUNITY (2004)
Mechanism of transforming growth factor β-induced inhibition of T helper type 1 differentiation
L Gorelik et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Betaglycan inhibits TGF-β signaling by preventing type I-type II receptor complex formation -: Glycosaminoglycan modifications alter betaglycan function
O Eickelberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase
CW Jang et al.
NATURE CELL BIOLOGY (2002)
X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-β signaling
SB Reffey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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