LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma

Article Oncology

Comprehensive Analysis of Immune Implications and Prognostic Value of SPI1 in Gastric Cancer

Jianfeng Huang et al.

Summary: The transcription factor SPI1, also known as PU.1, plays a critical role in determining the prognosis of gastric cancer patients and may serve as a potential immunotherapeutic target.

FRONTIERS IN ONCOLOGY (2022)

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Article Engineering, Biomedical

Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance

Yumin Zhang et al.

Summary: This study aimed to overcome radioresistance in tumors by regulating the polarization of tumor-associated macrophages (TAMs) using a toll-like receptor agonist TLR7/8a conjugated with a radiosensitive peptide hydrogel (Smac-TLR7/8 hydrogel). The results showed that the Smac-TLR7/8 hydrogel effectively polarized TAMs into an anti-tumor M1 phenotype upon gamma-ray radiation. The repolarization of TAMs promoted tumor necrosis factor secretion, activated the anti-tumor immune response, and inhibited tumor growth. Furthermore, TAMs repolarization enhanced the efficacy of PD1-blockade by increasing tumor infiltrating lymphocytes (TILs) and decreasing Treg cells in solid tumors.

BIOACTIVE MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Yue Wang et al.

Summary: The activation of the Wnt/β-catenin signaling pathway attenuates lipid ROS production in gastric cancer cells and inhibits ferroptosis. The β-catenin/TCF4 transcription complex induces the expression of GPX4, suppressing ferroptotic cell death. TCF4 deficiency promotes cisplatin-induced ferroptosis.

CELL DEATH AND DIFFERENTIATION (2022)

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Review Immunology

Tumor-Associated Macrophages Regulate PD-1/PD-L1 Immunosuppression

Yunzhou Pu et al.

Summary: This review summarizes the roles and mechanisms of tumor-associated macrophages (TAMs) in the resistance of PD-1/PD-L1 inhibitors. Various therapies, including inhibition of TAM differentiation and re-education of TAM activation, are available to recover the anticancer efficacy of PD-1/PD-L1 inhibitors.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer

Hong-Tao Wang et al.

Summary: Ferroptosis is a novel form of cell death characterized by iron accumulation and redox imbalance. It has unique morphological and biochemical features and shows great potential in cancer treatment. Small molecules based on research by Brent R. Stockwell's lab have been developed to induce ferroptosis in cancer cells, and some FDA-approved drugs have been found to trigger ferroptosis as well. Radiotherapy and checkpoint therapy have also been found to induce ferroptosis, providing new strategies for cancer treatment.

FRONTIERS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy

Jing Su et al.

Summary: Radiation therapy plays a crucial role in cancer treatment, but the hypoxic microenvironment in solid tumors can affect its effectiveness. Ferroptosis, a newly discovered cell death mechanism, can enhance the radiosensitivity of hypoxic tumor cells by amplifying oxidative stress or inhibiting antioxidant regulation.

ANTIOXIDANTS (2022)

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Article Cell Biology

Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling

Zongwen Liang et al.

Summary: This study found that MALAT1 knockdown could promote ferroptosis upon Erastin treatment through regulating the miR-145-5p/MUC1 signaling pathway, suggesting a potential therapeutic strategy for endometriosis.

CELL DEATH DISCOVERY (2022)

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Article Oncology

High Expression Levels of SIGLEC9 Indicate Poor Outcomes of Glioma and Correlate With Immune Cell Infiltration

Heng Xu et al.

Summary: This study investigates the diagnostic value and underlying mechanisms of SIGLEC9 in gliomas. It is found that high expression of SIGLEC9 is associated with malignant pathological types and poor survival probability.

FRONTIERS IN ONCOLOGY (2022)

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Review Pharmacology & Pharmacy

Long non-coding RNAs: From disease code to drug role

Yuanyuan Chen et al.

Summary: Extensive studies have shown that long non-coding RNAs (lncRNAs) play crucial roles in physiological processes and are closely linked to various diseases. Using lncRNAs as biomarkers or intervention targets can provide new perspectives for disease diagnosis and treatment. Research is shifting towards utilizing lncRNAs as pharmacological targets, with a focus on preclinical research and clinical trial progress.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Pharmacology & Pharmacy

LncRNAs in tumor microenvironment: The potential target for cancer treatment with natural compounds and chemical drugs

Qiu-Ping Liu et al.

Summary: Abnormal expression of lncRNAs in the tumor microenvironment typically leads to increased proliferation, migration, and drug resistance of tumor cells, however, regulating the expression of lncRNAs in TME can significantly inhibit tumor progression.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

The mechanisms and reversal strategies of tumor radioresistance in esophageal squamous cell carcinoma

Hongfang Zhang et al.

Summary: ESCC, a lethal malignancy with high aggressive potential, is resistant to radiotherapy mainly due to the influence of factors like CAFs, cancer stemness, and non-coding RNAs. Studying the mechanisms of resistance and reversal strategies can lead to the development of new intervention approaches.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Ernesto Rodriguez et al.

Summary: Changes in glycosylation during tumour progression, specifically the increased sialylation in PDAC tumour cells, can modulate immune cells such as monocyte-derived macrophages through Siglec receptors, leading to the generation of immune suppressive tumour associated macrophages.

NATURE COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression

Fang Zuo et al.

Summary: The study indicates that NR2F1-AS1 may promote proliferation, invasion, and migration of gastric cancer cells by recruiting SPI1 to upregulate ST8SIA1 expression. The regulation of their expression levels could provide a new direction for the treatment of gastric cancer.

BIOENGINEERED (2021)

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Article Oncology

Development and Validation of a Prognostic Gene Signature Correlated With M2 Macrophage Infiltration in Esophageal Squamous Cell Carcinoma

Jiannan Yao et al.

Summary: This study established and validated a novel 10-gene signature associated with M2 macrophages and poor prognosis in ESCC patients. Importantly, C1QA, C3AR1, LCP2, SPI1, and TYROBP were identified as novel M2 macrophage-correlated survival biomarkers, indicating potential therapeutic targets in ESCC patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Chemistry, Medicinal

Mucin1 and Mucin16: Therapeutic Targets for Cancer Therapy

Dong-Hee Lee et al.

Summary: The MUC family is highly glycosylated macromolecules abundantly expressed in mammalian epithelial cells, contributing to the mucus barrier formation against infection. Some MUC proteins are aberrantly expressed in cancer cells, involved in cancer development and progression, regarded as promising therapeutic targets and biomarkers.

PHARMACEUTICALS (2021)

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Article Oncology

Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis

Yinu Wang et al.

Summary: The study identifies platinum-tolerant cancer cells with cancer stem cell features characterized by expression of FZD7 and dependency on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival. These cells are highly susceptible to ferroptosis, marking a novel therapeutic vulnerability in platinum-resistant cancer cells.

CANCER RESEARCH (2021)

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Article Cell Biology